The Effect of Standardized Ginseng Extract on Peri- pheral Blood Leukocytes and Lymphocyte Subsets: A Preliminary Study in Young Healthy Adults
SURANGRAT SRISURAPANON, M.Sc.*, SUNTAREE APIBAL, M.Sc.*, RUEANGSAK SIRIPOL, M.D.***, KANYARAT RUNGROENG, M.Sc.**, PIPAT CHERDRUGSI, M.Sc.**, VANIDA VANICH-ANGKUL, B.Sc.*, CHUCHART TIMVIPARK, B.Sc.*
Affiliation : *Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, **Exercise Physiology Division, Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, ***Sports Science Center, The Sports Authority ofThai1and, Bangkok 10240, Thailand.
Abstract The present study was undertaken in twenty young, healthy Thai males to investigate the effects of prolonged administration of standardized ginseng extract on peripheral blood leukocytes and lymphocyte subsets. The subjects were divided into two equal groups as ginseng and placebo groups. The first group received two capsules daily of standardized ginseng extract 150 mg per capsule for 8 weeks. The second group received placebo and served as control. Circulatory levels of total and differential leukocyte counts and percentage of lymphocyte subsets were determined prior to and at the 4th and 8th week of the experimental period. There were no significant dif- ferences in the total and differential leukocyte counts as well as the lymphocyte subpopulations: CD3 (T cells), CD 19 (B cells), CD4 (T-helper cells), CD8 (T-suppression cells), CD4/CD8 ratio, and CD25 (lnterleukin-2-receptor cells) between the two subject groups throughout the experi- mental period. We concluded that oral administration of standardized ginseng extract, 300 mg/day for 8 weeks caused no significant changes in peripheral blood leukocytes and lymphocyte sub- sets in young, healthy Thai males.
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