Increasing the Chance to Accept HLA-ABDR Mis- matched Donor in Kidney Transplantation
KANCHANA SUJIRACHATO, Ph.D.*, TASANEE MONGKOLSUK, M.Sc.*, VASANT SUMETHKUL, M.D.**, SUTHUS SRIPHOJANART, M.D.***, PIMOL CHIEWSILP, M.D.*, SUREEPORN JUNPONG, B.Sc*, SOPON JIRASIRITHAM, M.D.***, SIROJ KANJANAPANJAPOL, M.D.***, SOMNUEK DOMRONGKITCHAIPORN, M.D.**
Affiliation : *Department of Pathology, ** Department of Medicine, ***Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Abstract
Two hundred and fifty-three kidney transplantations (KT) which included 68 (26. 9o/c)
living-related (L) and 185 (73.1 o/c) cadaveric (C) KT with 0-6 HLA-ABDR mismatches (MM)
were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft
rejection (GR). It was found that the incidence of acute and chronic rejection in CKT was sig-
nificantly higher than that of LKT ( 42.1% vs 22.1 %, p<0.005). It was also observed that the
number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in
CKT compared with LKT. The analysis revealed that HLA-All, B 16, B22, B35, B5, B 17 and
DR3 were good responders, whereas, HLA-A30, A2, B62, Bl8, B40, B44, B46 and DRIO were good
stimulators for KT. GR were significantly increased with p Keywords :
