HLA Gene Frequencies of Northern Thais
LADDA FONGSATIKUL, M.Sc.*, NUONCHUEN KAMTORN, B.Sc.*, NIWES NANTACHIT, M.D.**, NIPAPAN LEETRAKOOL, B.Sc.*
Affiliation : * Blood Bank Section, Chiang Mai University, ** Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Abstract
We investigated the distribution of HLA-A and B locus, gene frequency (GF), antigen
frequency (AF), haplotype frequency (HF) and non detectable antigens in Northern Thais. Of 289
native northern Thai people residing in Chiang Mai province for many generations were tested
using lymphocytotoxicity test and 146 unrelated subjects were selected for analysis. The com-
mon alleles were A2, All and A24 for A locus with GF of 36.4%, 35.4% and 15.6%, respectively
and B46, B40 and Bl3 forB locus with GF of 21.1%, 15.7% and 8.6%, respectively. The frequent
linkage disequilibrium haplotypes were A2,B46; A33,B 17 with HF of 15.9%; 5.0% and LD of
8.3%; 4.6%, respectively (p Keywords :
