HLA Class II Allele Frequencies in Northern Thais (Kamphaeng Phet)
RATCHANEEWAN MANEEMAROJ, M.Sc.*, DASNAYANEE CHANDANAYINGYONG, M.D.**, HENRY A.F. STEPHENS, Ph.D.**, KOMON LONGTA, M.Sc.**, SASITORN BEJRACHANDRA, M.D.**
Affiliation : * Department of Pathology, Pramongkutklao College of Medicine, Bangkok 10400, ** Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Abstract The polymorphism of HLA class II genes (HLA-DRBl, -DQA1, -DQBl and -DPBl) was investigated in 97 normal Northern Thais (NT) from Kamphaeng Phet province using PCR-SSO typing. Allele frequencies (AF) have been determined. DRB 1 * 1202 ( 17.5% ), DRB 1 * 1502 (16.5%), DQA1*0101 (25.8%), DQA1*0102 (21.7%), DQB1*0502 (22.7%), DPB1*0501 (23.2%) and DPB1*1301 (22.7%) showed the highest frequencies in each locus. These results were more similar to those observed in Present-day Thais (PDT) and Central Thais (CT) than Northern Thais from Chiang Mai (CM) and Dai Lue (DL). However, the data presented in this population study should be useful in many fields, such as anthropology, organ transplantation, disease suscep- tibility and evolutionary genetics.
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