Effect of Dialyzer Membranes on Beta-2 Microglobulin Production in Thai Hemodialysis Patients
SOMNUEK DOMRONGKITCHAIPORN, M.D.*, NAPAPORN ARCHARARIT, M.Sc.***, SUPORN CHUNCHARUNEE, M.D.*, KALA Y ANEE AT AMASIRIKUL,M.Sc. **, SUPAT VANICHAKARN, M.D.*****
Affiliation : * Department of Medicine, ** Department of Pathology, *** Research Center, Ramathibodi Hospital, Mahidol University, Bangkok 10400, **** The Kidney Foundation of Thailand, Siriraj Hospital, Bangkok 10700, Thailand.
Abstract Responses to different types of dialyzer membranes in an Asian population may differ from those of a Caucasian population. Comparative studies on the effects of different dialyzer membranes on beta-2 microglobulin production are also limited. Therefore, we conducted this study to determine the effects of different dialyzer membranes on in vitro mononuclear cell pro- duction of beta-2 microglobulin in 9 Thai hemodialysis patients. Each patient was dialysed with 4 different types of dialyzer, including cuprophane (CUP), cellulose diacetate (CD), polysulphone (PS), and polyacrylonitrile membrane (PAN), each for a 1-month period in a randomized sequence. Mononuclear cell culture was done by taking an immediate post-dialysis blood sample at the end of the 1-month period. Beta-2 microglobulin production from cell culture was determined 24 hours later. Mononuclear cell culture and determination of beta-2 microglobulin production from the culture were also done in 10 normal controls and 10 predialysis ESRD patients. The beta-2 micro- globulin productions (jlg/L) were shown as follows; Conclusion: polysulphone and polyacrylonitrile membrane induced significantly less beta-2 micro- globulin production compared to cuprophane and slightly less compared to cellulose diacetate membrane.
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