Azithromycin in the Treatment of Chlamydia) Cervicitis and Eradication of Ureaplasma Urealyticum in Female Lower Genital Tract
ANGKANA CHAROENW ATANACHOKCHAI, M.D.*, PATCHARA SIRIWONGRANGSUN, M.D.*, NARUEMOL YENYASUN, R.N.*, ANUPONG CIDTW ARAKORN, M.D., Dip. Ven. *, WANIDA PARIYASAK, R.N.*, SUCIDTRA SUKWIT, M.Sc.**
Affiliation : * Venereal Disease Control Division, Department of Communicable Disease Control, Ministry of Public Health, Bangkok 10120, ** Armed Forces Research Institute of Medical Science, Bangkok 10400, Thailand.
Abstract From May 1995 to May 1996, thirty-six females with chlamydia! cervicitis were enrolled at Bangrak Hospital's Venereal Disease Clinic in an open study to assess the efficacy and safety of a single, 1-gram oral dose of azithromycin. Thirty-five had positive C. trachomatis and one had a positive Gen-probe test. Twenty-two returned for their first and second follow-ups and 18 came back for their final follow-up (visit 4). Eradication rate was 100 per cent on all visits. Fourteen patients were excluded from the final analysis- three had dropped out from the beginning, ten had sexual intercourse without a condom and one had a positive Gen-probe test but negative C. trachomatis culture. U. urealyticum was isolated from the vaginal wall of 15 of the 36 cases and eradication rate was 0 per cent at visit 2 and visit 4. In conclusion, this study shows that a single, 1-gram oral dose of azithromycin is an effective and well-tolerated alternative therapy for chlamydia! cervicitis.
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