AntitriiodothyronineAntibody in Patient with Hashimoto's Thyroiditis
NATTACHET PLENGVIDHYA, M.D.*, THONGKUM SUNTHORNTHEPV ARAKUL, M.D.**, SATHIT V ANNASAENG, M.D.*
Affiliation : * Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, * * Department of Medicine, Rajavithi Hospital, Bangkok 10400, Thailand. t Presented at 8th Annual Meeting of Endocrine Society of Thailand Bangkok, November 1Oth, 1995.
Abstract We described a 44-year-old female patient with a history of goiter for 2 months. Physical examination revealed a diffusely enlarged thyroid gland weighing 40 g firm to hard in consistency. She was clinically euthyroid and had neither ophthalmopathy nor dermopathy. Serum thyroid hormone levels revealed total T4 (RIA) of 4.8 flg/dL (normal, 4-11 flg/dL), total T 3 (RIA) of above 600 ng/dL (70-175 ng/dL), and TSH (IRMA) of 54 mUlL (0.3-6 mUlL). Antithyroglobulin and antiperoxidase antibody titers were 1:5,120 and 1:409,260, respectively. Because of the dis- crepancy between the patient's clinical status and laboratory values, assay for thyroid hormone autoantibodies (THAA) was done and subsequently demonstrated antitriiodothyronine antibody with percentage of precipitation by polyethylene of 98.4 per cent (normal range, 3.06±8.58%). In conclusion, THAA should be suspected in patients whose clinical status is incoherent with the thyroid function test.
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