Effect of Pravastatin in Treatment of Hypercholes- terolemia in Non-insulin-dependent Diabetes Patients

SUPAMAI SOONTHORNPUN, M.D.*, RATTAN A LEELA WATT ANA, M.D.*, CHATCHALIT RATTARASARN, M.D.*, ATCHARA THAMPRASIT, B.N.*

Affiliation : * Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Prince of Songkla Uni- versity, Hat-Yai, Songkhla 90112, Thailand.

Abstract To evaluate the efficacy of pravastatin in treatment of hypercholesterolemia in non-insulin- dependent diabetes patients, a 6-month trial of once daily 10 mg-pravastatin was studied in 30 patients with fairly, well controlled non-insulin-dependent diabetes mellitus. For 27 patients who completed the study, serum total cholesterol and low-density lipoprotein cholesterol were signifi- cantly lower 16.7±2.3 and 20.2±3.3% from 286.7±5.9 and 198.6±7.2 mg/dl at before to 232.6±7.9 and 147.8±6.4 mg/dl at 4th week and 237.8±6.4 and 155.0±5.8 mg/dl at 24th week after treatment with pravastatin, respectively (P0.05). There was no seriou3 adverse effect except acute hepatitis in one patient who recovered spontaneously after drug withdrawal. Once daily 10 mg-pravastatin is effective in the treatment of hypercholesterole- mia in patients with non-insulin-dependent diabetes mellitus.

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