Effect of Postmenopausal Hormone Replacement Therapy on the Impedance of Internal Carotid Artery
Bai Wen-Pei*, Zheng Shu-Rong*, Yang Xin*, Chen Shu-Ling*, Li Hui*
Affiliation : *Department of Obstetrics and Gynecology, The First Hospital of Beijing Medical University, Beijing. China. 100034
Objective: To determine the effects of postmenopausal hormone replacement therapy
on the impedance of internal carotid artery of Chinese postmenopausal women.
Method: Thirty-six women were recruited who were 40-65 years old, menopause more
than six months, serum estradiol <20 pglml. They did not have cardiovascular disease. Patients
were separated 2: I randomly into control and experimental groups. 0.625 mg conjugated
estrogen used as control drug, I mg domestic estradiol valerate was studied. 4 mg medroxypro-
gesterone acetate was added sequentially. Pulsatility index (PI). resistance index (RI) and SID
ratios were measured with Doppler before and after treatment (9 week). Serum estradiol and
FSH were measured at the same time.
Results: Both of the two drugs reduced PI, RI and SID ratio of internal carotid artery of
postmenopausal women. Serum estradiol was enhanced to the early follicle phase level. There
was no significant difference between two groups.
Conclusion: Postmenopausal hormone replacement therapy reduces the impedance of
internal carotid artery.
MeSH: Hormone replacement therapy, pulsatility index, resistance index, SID ratio,
internal carotid artery.
Keywords :
