Prognostic Importance of p53 and c-erbB-2 Oncopro- teins Overexpression in Patients with Breast Cancer
SUNANTA CHARIYALERTSAK, M.Sc.* SUWAT CHARIYALERTSAK, M.D., Ph.D.**, ARKOM CHEIRSILPA, M.D.* KITI CHINDAVUAK,M.D.,F.A.C.S.,F.R.C.S.T.,F.I.C.S.*
Affiliation : * National Cancer Institute, Bangkok 10400, ** Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Abstract
Using immunohistochemistry, 119 breast cancer tissues were examined for overexpres-
sion of p53 and c-erbB-2 oncogene proteins. In 46 (38.7%) of the cases p53 was overexpressed,
while 35 (29.4%) demonstrated positive c-erbB-2 immunostaining. Expression of these two onco-
gene products was closely correlated (p Keywords :
