In Vitro Activity and Clinical Evaluation of Cefixime in Urinary Tract Infection
KORNTONG ASV ANICH, M.D.*, SOMBOON SRIMUANG, M.Sc.**, VICHAI FUGPHOLNGAM, M.D.*, DEJA TANPHAICHITRA, M.D.***
Affiliation : * Department of Family Medicine, ** Research Center, *** Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok l 0400, Thailand.
Abstract
Thirty-five women with uncomplicated acute lower urinary tract infections proven by
significant pre-treatment bacteriuria (~ I05CFU/ml) were treated with an oral dose of 100 mg
cefixime twice a day for seven days.
Thirty five patients included in this study were checked for response to treatment on the
last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial
eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and
Proteus mirabilis, were inhibited at MIC90= 0.5 and ~ 0.03 jlg/ml, and MBC = 1 and 0.06
jlg/ml respectively. No adverse events were found in this study.
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