A Comparison Between 25 Micrograms and 50 Micro- grams of Intravaginal Misoprostol for Labor Induction
JATUPOL SRISOMBOON, M.D.*, SUREE SINGCHAI, M.D.*
Affiliation : *Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Abstrad Our purpose was to compare the efficacy 2:5 11g and 50 ug dosage of intravaginal miso- prostol for labor induction in patients with an unfavorable cervix. Fifty pregnant women were randomly assigned to receive either 25 11g (24 cases) or 50 jlg (26 cases) of intravaginal miso- prostol every 6 hours. The mean interval from induction to vaginal delivery was significantly shorter in the 50 jlg group (13.8 ± 6.6 hours) when compared with the 25 jlg group (20.9 ± 9.5 hours) (P = 004). The average number of misoprostol doses needed per patient was signifi- cantly fewer in the 50 jlg group (1.6 ± 0.7 versus 2.3 ± 1.2, P = 0.018). The frequencies of uterine tachysystole were 4.2 per cent and 7.7 per cent in the 25 11g and 50 jlg groups respectively which did not significantly differ. Requirement for oxytocin infusion in the 25 jlg group was sig- nificantly more than in the 50 11g group (66.6 % versus 23.1 % respectively, P = 0.004 ). Anal- gesia requirement, delivery method, and perinatal outcomes were comparable in both groups. In summary, intravaginal application of 50 jlg misoprostol at 6-hour interval is comparable in safety but more effective for labor induction than the 25 jlg dosage.
Keywords :
