Single Daily Dose of Gentamicin in the Treatment of
Pediatric Urinary Tract Infection
CHALEOMSRI TAPANEYA-OLARN, M.D.*,
VICHIT PITAYAMORNWONG, M.D.*,
KANCHANA TANGNARARATCHAKIT, M.D.*
WIWAT TAPANEYA-OLARN, M.D.*,
THAN OM PETCHTHONG, B.Sc. **,
Affiliation : * Department of Pediatrics,
** Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
AbstractFourty-nine patients aged 6 months to 12 years old with suspected urinary tract infec-
tion (UTI) were evaluated in this open randomized study. Twenty-seven patients received
gentamicin 4.5 mg/kg/d once daily (OD group) and 22 patients received the same daily dose in
three divided doses (TID group) for 3 days before being switched to amoxy-clavulanic acid.
Ninety-six per cent (26/27) of the OD group had peak gentamicin within therapeutic level while
40 per cent (9/22) of the TID group had peak gentamicin within therapeutic level. One in OD
group had high gentamicin level due to technical error in obtaining blood sample. None in
neither group had trough level in toxic level. Only 24 patients had confirmed UTI and were
evaluated for clinical efficacy and toxicity. Demographic data were the same in both groups
except there were more males in OD group (8:3 vs 4:9). Patients in OD group became afebrile
earlier than TID group (8.69 vs 15.31 hours) but no statistically significant difference. All patients
had negative urine culture results within 48 hours. None had clinical nephrotoxicity in both
groups. More patients in TID group had laboratory nephrotoxicity (5111 vs 2/l3) but no statis-
tically significant difference.
We conclude that gentamicin can be given safely and efficiently as single daily dose
or thrice daily but more cost effective and less time consuming in once daily dose.
Keywords : Gentamicin, Pediatric, Urinary Tract Infection
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