Effects of Thna Fish Oil on Hyperlipidemia and Proteinuria in Childhood Nephrotic Syndrome
NALINEE CHONGVIRIYAPHAN, M.D.*,
UMAPORN SUTHUTVORA VUT, M.D.*,
VINITA CHANTRARUKSA, B.H.E. ***
CHALEOMSRI TAPANEYA-OLARN, M.D.*,
SAOW ANEE KARNCHANACHUMPOL, M.S.**,
Affiliation : * Department of Pediatrics,
** Research Center,
*** Division of Food and Dietetics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok l 0400.
Thailand.
AbstractThis is a randomized, double-blind, placebo-controlled, cross-over study to deter-
mine whether tuna fish oil decreased hyperlipidemia and proteinuria in children with steroid-
resistant nephrotic syndrome. Five boys were supplemented with both 4 grams of tuna fish oil
and placebo in a randomized order for 8 weeks of each treatment separated by 6-week wash-
out period. The results showed no statistically significant difference in serum creatinine, triglyceride,
cholesterol, urine protein and creatinine clearance between fish oil supplemented group and
placebo group. Small sample size, low dosage, short duration of supplementation and wash-out
period are among the important limitations in this study. Further study should be performed to
identify the effects of fish oil on this entity in nephrotic syndrome.
Keywords : Fish Oil, Hyperlipidemia, Nephrotic Syndrome
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