Maternal and Umbilical Cord Serum Vitamin A, E Levels
and Mother-to-Child Transmission in the Non-Supple-
mented Vitamin A, E HIV-1 Infected Parturients with
Short-Course Zidovudine Therapy
AMORNPUN WIRATCHAI, M.D.*,
RUJANEE SUNTHORNKACHIT, M.D.*,
PREECHA TANTANATHIP, M.D.*,
WINIT PHUAPRADIT, M.D.**,
ACHARA CHAOVAVANICH,M.D.*,
ORA WAN PUCHAIWATANANON, D.Sc.***
Affiliation : * Bamrasnaradura Hospital, Infectious Disease Control Division, Ministry of Public Health, Nonthaburi II 000.
** Department of Obstetrics and Gynaecology,
*** Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok I 0400, Thailand.
AbstractThis study was undertaken to assess the maternal and umbilical cord serum vitamin A, E
levels at delivery and mother-to-child transmission in nonsupplemented vitamin A, E HIV -1
infected parturients who received short-course zidovudine therapy. Maternal and umbilical cord
serum vitamin A, E levels were quantitated by high-performance liquid chromatography in 67 HIV-1
infected parturients who received short-course zidovudine therapy. Mother-to-child transmission
occurred in 13.4 per cent of HIV -1 infected parturients. There were no significant differences in
the mean concentrations of vitamin A, E and vitamin E/cholesterol ratio between parturients
with HIV -1 infected and non-infected infants. While maternal serum vitamin E level was adequate,
nearly one-third of the parturients in the study had vitamin A deficiency. In conclusion our
study has shown that there was no correlation between maternal serum vitamin A, E levels and
mother-to-child HIV transmission in HIV -1 infected parturients who received short-course
zidovudine therapy. However, the presence of underlying vitamin A deficiency in these par-
turients was common, adequate and intensive maternal-infant nutritional snpport should be
emphasized especially in developing countries as an adjunctive measure in the reduction of
mother-to-child transmission of HIV as well as the reduction in maternal and perinatal mor-
bidity.
Keywords : Serum Vitamin A, E, Mother-to-Child HIV Transmission
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