The Efficacy of rltemically-Stabili~e£! Chlorite-Matrix
(TCDO*) in the Management of Late Postradiation
Cystitist
SOMKEART SRISUPUNDIT, M.D.*,
SUPATRA SANGRUCHI, M.D.***,
KIA TIC HAl CHINGSKOL, M.D.*,
PUANGTONG KRAIPHIBUL, M.D.**,
VAS ANT LIN AS MIT A, M.D.*,
VUTISIRI VEERASARN, M.D.***
Affiliation : * Department of Obstetrics and Gynecology,
** Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok I 0400,
*** Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
t The chemically-stabilized chlorite-matrix, in the literature referred to as tetrachlorodecaoxygen anion complex
or TCDO, has been registered in Thailand under the name IMMUNOKINE®
AbstractCarcinoma of the uterine cervix is the most common cancer of women in Thailand. The
most frequent complication after pelvic radiation for uterine cancer is radiation cystitis. The
management of severe late postradiation cystis is far from satisfactory. The objective of this
study was to evaluate the efficacy of chemically-stabilized chlorite-matrix (TCDO) in patients
with severe radiation cystitis. This study was conducted at the Department of Obstetrics and
Gynecology, Ramathibodi Hospital and the Department of Radiology, Siriraj Hospital between
September 1997 and September 1998. Twenty patients with grade 3 radiation cystitis after radio-
therapy were enrolled into this study. TCDO was administered at a dose of 0.5 ml/kg body weight
per day on 5 consecutive days as intravenous infusion over 4 hours. The response rate after the
first cycle was 80 per cent with 30 per cent of the patients showing complete response. The follow-
up time (13 patients) ranging from 1-9 months revealed no recurrent bleeding. There were no side
effects from TCDO therapy. The result suggests good efficacy of TCDO in the treatment of post-
radiation cystitis.
Keywords : Radiation Cystitis, TCDO
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