Hemodynamic Responses to Captopril During Splenec- tomy in Thalassemic Children

VORAPA SUWANCHINDA, M.D.*, SANGSOM PIRAYAVARAPORN,M.D.*, MONGKOL LAOHAPENSANG, M.D.*** VORA V ARN TANPHAICHITR, M.D., M.S.**, PRADIT SOMPRAKIT, M.D.*,

Affiliation : * Department of Anesthesiology, ** Department of Pediatrics, *** Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

AbstractSplenectomy in B-thalassemic children is frequently accompanied by perioperative hyper- tension which occasionally is followed by convulsion. The efficacy of captopril in attenuating the hypertensive response to splenectomy was investigated in 82 thalassemic children. The control group, consisting of 40 patients, received intravenous f!_[osemide (I mg/kg) preoperatively; whereas, 42 children were randomly allocated into 2 groups to receive oral captopril (0.7 mg/kg) or a combination of captopril (0.7 mglkg) and furosemide (1 mg/kg) before the operation.
Before anesthetic induction, both systolic and diastolic arterial pressures in the captopril and the combined groups were significantly lower than the furosemide group (P

Keywords : Thalassemia, Splenectomy, Hypertension, Captopril

All Articles Download

Information

Related Links