Background: Coronary artery disease (CAD) is known to be a leading cause of death. Although many studies have revealed a relationship between rate-pressure product and significant coronary artery stenosis in patients with a positive exercise stress test, there have been few studies on the subject in Thailand. Rate-pressure product results were reviewed of exercise stress tests performed at a single center in Thailand.
Objective: To determine a relationship between rate-pressure product and significant coronary artery stenosis in patients with positive exercise stress test.
Material and Method: A retrospective cross-sectional study was performed by collecting medical records of patients who had a positive exercise stress test confirmed by cardiac catheterization in Rajavithi Hospital between 1 January 2009 and 31 December 2014.
Results: A total of 126 patients were enrolled. Eighty-six patients (68.3%) were male, the mean age was 58.09+8.67 years and the mean body mass index was 25.60+3.55 kg/m2. Although the study found that patients in the group with rate-pressure product >30,000 bpm⋅mmHg had more non-significant coronary artery stenosis (35.3%) than those in the group with ratepressure product <30,000 bpm⋅mmHg (20.02%), the differences were not statistically significant (p-value = 0.163). The group without significant coronary artery stenosis had a higher mean rate-pressure product (27,370.75+5,190.89 bpm⋅mmHg) than the group with significant coronary artery stenosis (22,605.50+5,588.57 bpm⋅mmHg) (p-value <0.001).
Conclusion: A high rate-pressure product (>30,000 bpm⋅mmHg) is not associated with coronary artery stenosis in patients with positive exercise stress test. Patients without significant coronary artery stenosis had a higher average rate-pressure product.

Keywords: Rate-pressure product, Double product, Coronary artery stenosis, Cardiac catheterization, Exercise stress test