Background: Tiliacora triandra (T. triandra) leaf is widely used as an ingredient in Thai cuisine, but the activity of T. triandra leaf water extract (TTW) in the regulation of metabolic syndrome is still little known.
Objective: To examine the effects of TTW in high-fat diet (HFD)-induced obese mice.
Material and Method: Male ICR mice were induced to be obese by HFD feeding (45 kcal % lard fat) for 12 weeks. During the last 6 weeks of diet feeding, the obese mice were treated with TTW at 250 and 500 mg/kg/day. The biochemical parameters and histology analysis were measured at the end of treatment period.
Results: After 6 weeks of TTW treatment, the hyperglycemia, hyperinsulinemia hyperleptinemia and hyperlipidemia were significantly decreased. Hepatic lipid accumulation and adipocyte hypertrophy were also reduced. Serum adiponectin was increased in TTW-treated obese mice. TTW treatment could reduce the malondialdehyde in serum and liver tissue. Furthermore, the elevated serum inflammatory cytokines, tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 were reduced (MCP-1) by TTW.
Conclusion: These results suggest that T. triandra leaf is a beneficial plant in alleviating hyperglycemia, hyperlipidemia, oxidative stress, and inflammation in the obese condition induced by HFD.

Keywords: Tiliacora triandra, Obesity, Insulin resistance, Hyperlipidemia, Oxidative stress, Inflammation