Deferiprone (DFP), an oral chelation therapy, has improved treatment adherence and quality of life of transfusion
dependent thalassemia (TDT). DFP-induced arthropathy is usually mild and self-limited; the severe DFP-induced arthropathy is uncommon presentation. Herein, a Thai girl diagnosed as TDT was initially treated with DFP. She subsequently developed severe DFP-induced bilateral knee arthritis despite discontinuing DFP and using non-steroidal anti-inflammatory drugs (NSAIDs). She was treated with arthrocentesis and intraarticular triamcinolone acetonide injection and responded well to the treatment.

Keywords: Deferiprone, Thalassemia, Arthropathy, Triamcinolone acetonide