Acute motor axonal neuropathy (AMAN), a variant of Guillain-Barré syndrome (GBS), is characterized with acute paralysis and loss of reflexes. This was a case report of AMAN patient presenting with paraparesis and hyperreflexia. We reported a 1-year-11-month-old boy hospitalized with history of two weeks of progressive ascending paralysis. He had upper respiratory tract infection four weeks prior to the onset of weakness. Physical examination showed paraparesis with exaggerated tendon reflexes; furthermore, he was evaluated for spinal cord lesion, which showed normal MRI spine. Lumbar puncture showed CSF cytoalbuminologic dissociation. Moreover, nerve conduction studies showed motor axonal degeneration. His clinical signs improved spontaneously and complete recovery at eight weeks after the onset of weakness. This case implied the clinicians’ extra attention for GBS with hyperreflexia and paraparesis.

Keywords: Acute motor axonal neuropathy, Guillain-Barré syndrome, Tendon reflex, Hyperreflexia, Anti-gangliosides antibody, Campylobacter jejuni