Most cases of severe malaria are caused by infection of Plasmodium falciparum. However, severe manifestations
in the infection of P. knowlesi and P. vivax have been reported in recent years. The present study reported a 24-year-old Thai
male presenting with acute fever and shock. Both blood smears and PCR were positive for P. vivax. He was treated with
intravenous artesunate for 3 days in combination with oral mefloquine for 2 days and oral primaquine for 14 days. He was
discharged from hospital without any sequelae.

Keywords: Severe vivax malaria, Plasmodium vivax, Shock, Thailand