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Original ArticleOpen Access
Candida Species, Genotypes and Antifungal Susceptibility of Candida Isolates from Blood Samples of Patients at the Largest Tertiary Care Hospital in Thailand During 1999-2002
Foongladda S 
,
Sakulmaiwatana P ,
Petlum P ,
Vanprapar N
,
Sakulmaiwatana P ,
Petlum P ,
Vanprapar N From 1999 to 2002, a total of 202
Candida
isolates causing candidemia were recovered from
202 individual patients in the largest tertiary hospital in Bangkok, Thailand. C.
albicans
comprised 44.55
per cent of all isolates.
Non-albicans Candida
spp. isolates accounted for 55.45 per cent of all candi-
demia episodes and were primarily due to C.
tropicalis
(45%) followed by C.
parapsilosis
(6%), C.
glabrata
(4%), and C.
krusei
(0.5l7o).
Non-albicans Candida
spp appeared more frequently in children
(59%). Regarding etiology,
non-albicans Candida
spp showed an increase (67%) in the year 2002. The
distribution of C.
albicans
genotypes was as follows: genotype A, 71 per cent; genotype B, 26 per cent
and genotype C, 3 per cent, with a similar susceptibility proportion to amphotericin B, fluconazole and
itraconazole. All isolates of C.
albicans,
C.
tropicalis,
and C.
parapsilosis
were susceptible to fluco-
nazole
in vitro.
Only 16.7-19.8 per cent of the isolates were resistant to itraconazole. A high proportion
of C.
glabrata
isolates showed drugs resistance.
Key word : Candidemia,
Candida
species, Genotypes, Drug Susceptibility
Candida
isolates causing candidemia were recovered from
202 individual patients in the largest tertiary hospital in Bangkok, Thailand. C.
albicans
comprised 44.55
per cent of all isolates.
Non-albicans Candida
spp. isolates accounted for 55.45 per cent of all candi-
demia episodes and were primarily due to C.
tropicalis
(45%) followed by C.
parapsilosis
(6%), C.
glabrata
(4%), and C.
krusei
(0.5l7o).
Non-albicans Candida
spp appeared more frequently in children
(59%). Regarding etiology,
non-albicans Candida
spp showed an increase (67%) in the year 2002. The
distribution of C.
albicans
genotypes was as follows: genotype A, 71 per cent; genotype B, 26 per cent
and genotype C, 3 per cent, with a similar susceptibility proportion to amphotericin B, fluconazole and
itraconazole. All isolates of C.
albicans,
C.
tropicalis,
and C.
parapsilosis
were susceptible to fluco-
nazole
in vitro.
Only 16.7-19.8 per cent of the isolates were resistant to itraconazole. A high proportion
of C.
glabrata
isolates showed drugs resistance.
Key word : Candidemia,
Candida
species, Genotypes, Drug Susceptibility
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