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Original ArticleOpen Access
Subacute Infective Endocarditis Caused by Corynebacterium diphtheriae : A Case Report
Lolekha R 
,
Supradish P ,
Kirawittaya T ,
Srimaharaja S ,
Chotpitayasunondh T
,
Supradish P ,
Kirawittaya T ,
Srimaharaja S ,
Chotpitayasunondh T PRAON SUPRADISH, MD*,
SAKSAN SRIMAHARAJA, MD***,
The authors report an 11-year-old boy with septicemia and subacute infective endocarditis due
to
toxigenic-Corynebacterium diphtheriae.
The patient had underlying congenital heart disease and
incomplete immunization. He presented with fever, epistaxis and congestive heart failure. He received
high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. While he was receiving
a high dose of penicillin for 1 month he developed a generalized tonic clonic seizure. A computerized
tomogram revealed intracerebral and ventricular hemorrhage. Craniotomy with blood clot removal and
ventriculostomy drainage were done. He died 2 days later from brain death and cardiovascular failure.
Key word :
Corynebacterium Diphtheriae,
Endocarditis
SAKSAN SRIMAHARAJA, MD***,
The authors report an 11-year-old boy with septicemia and subacute infective endocarditis due
to
toxigenic-Corynebacterium diphtheriae.
The patient had underlying congenital heart disease and
incomplete immunization. He presented with fever, epistaxis and congestive heart failure. He received
high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. While he was receiving
a high dose of penicillin for 1 month he developed a generalized tonic clonic seizure. A computerized
tomogram revealed intracerebral and ventricular hemorrhage. Craniotomy with blood clot removal and
ventriculostomy drainage were done. He died 2 days later from brain death and cardiovascular failure.
Key word :
Corynebacterium Diphtheriae,
Endocarditis
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