Views: 1,244 | Downloads:
20
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Pattern of Drug Resistant Helicobacter Pylori in Dyspeptic Patients in Thailand
Tangmankongworakoon N 
,
Mahachai V ,
ThongNgam D ,
Vilaichone R ,
Tumwasorn S ,
Kullavamjaya P
,
Mahachai V ,
ThongNgam D ,
Vilaichone R ,
Tumwasorn S ,
Kullavamjaya P VAROCHA MAHACHAI, MD*,
RATHA-KORN VILAICHONE, MD*,
PINIT KULLA V ANUA YA, MB, ChB*
Emergence of drug resistant
Helicobacter pylori
(H.
pylori)
has occurred in various countries
and could compromise the efficacy of current treatment regimens. The aim of the study was to iden-
tify the pattern of antibiotic resistant
H.
pylori
in Thailand and evaluate various factors associated with
drug resistance. Between June 2001 and December 2002, a total of 560 dyspeptic patients who under-
went upper gastrointestinal endoscopy at King Chulalongkom Memorial Hospital were included in this
study. Antral gastric biopsies were obtained for
H.
pylori
cultures and susceptibility tests using Epsilo-
meter test (E-test). The value of antibiotic resistant breakpoints were amoxicillin 0.5 J..tg/ml, clarithro-
mycin 1.0 J..tg/ml, metronidazole 8 J..tg/ml, and tetracycline 4J..tg/ml, respectively.
H.
pylori
were detected
in 315 patients using the rapid urease test (56.25% ). Cultures for
H.
pylori
were positive in 172 patients.
E-test for all four antibiotics was successfully placed in 79 isolations. The prevalence of antibiotic
resistant
H.
pylori
were amoxicillin 13.9 per cent (11/79), clarithromycin 19.0 per cent (15/79), metro-
nidazole 30.4 per cent (24/79), tetracycline 5.1 per cent (4/79), and multi-drugs 16.5 per cent (13/79),
respectively. However, age, sex, or endoscopic findings did not differ between the patients with
H.
pylori
resistant strains and sensitive strains. The emergence of antibiotic and multi-drug resistant
H.
pylori
in Thailand were relatively high and these could compromise the efficacy of current treatment
regimens. The factors associated with drug resistant
H.
pylori
could not be demonstrated in the pre-
sent study. Further study in a larger number of patients might be necessary to identify factors asso-
ciated with resistant
H.
pylori.
Key word
:
Helicobacter Pylori,
Drug Resistance, Dyspeptic Patients, Thailand
RATHA-KORN VILAICHONE, MD*,
PINIT KULLA V ANUA YA, MB, ChB*
Emergence of drug resistant
Helicobacter pylori
(H.
pylori)
has occurred in various countries
and could compromise the efficacy of current treatment regimens. The aim of the study was to iden-
tify the pattern of antibiotic resistant
H.
pylori
in Thailand and evaluate various factors associated with
drug resistance. Between June 2001 and December 2002, a total of 560 dyspeptic patients who under-
went upper gastrointestinal endoscopy at King Chulalongkom Memorial Hospital were included in this
study. Antral gastric biopsies were obtained for
H.
pylori
cultures and susceptibility tests using Epsilo-
meter test (E-test). The value of antibiotic resistant breakpoints were amoxicillin 0.5 J..tg/ml, clarithro-
mycin 1.0 J..tg/ml, metronidazole 8 J..tg/ml, and tetracycline 4J..tg/ml, respectively.
H.
pylori
were detected
in 315 patients using the rapid urease test (56.25% ). Cultures for
H.
pylori
were positive in 172 patients.
E-test for all four antibiotics was successfully placed in 79 isolations. The prevalence of antibiotic
resistant
H.
pylori
were amoxicillin 13.9 per cent (11/79), clarithromycin 19.0 per cent (15/79), metro-
nidazole 30.4 per cent (24/79), tetracycline 5.1 per cent (4/79), and multi-drugs 16.5 per cent (13/79),
respectively. However, age, sex, or endoscopic findings did not differ between the patients with
H.
pylori
resistant strains and sensitive strains. The emergence of antibiotic and multi-drug resistant
H.
pylori
in Thailand were relatively high and these could compromise the efficacy of current treatment
regimens. The factors associated with drug resistant
H.
pylori
could not be demonstrated in the pre-
sent study. Further study in a larger number of patients might be necessary to identify factors asso-
ciated with resistant
H.
pylori.
Key word
:
Helicobacter Pylori,
Drug Resistance, Dyspeptic Patients, Thailand
Download:
PDF