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Case ReportOpen Access
Thrombolysis for Prosthetic Valve Malfunction : Case Report and Review
Chaiworramukkun J 
,
Chandanamattha MP ,
Boonbaichaiyapruck M
,
Chandanamattha MP ,
Boonbaichaiyapruck M A 40 year old female with severe mitral valve stenosis, underwent mitral valve replacement
by single disc valve 4 years ago. She presented at this admission with a new onset of congestive heart
failure. The prothrombin time was inadequate with international normalized ratio (INR) 1.43. Trans-
thoracic echocardiography revealed high pressure gradient across the mitral valve. Fluoroscopy demon-
strated restrictive opening of single disc motion. Intravenous thrombolysis was given for presumptive
diagnosis of prosthetic valve thrombosis. The patient gradually improved and did not have to undergo
surgical correction.
Key word : Prosthetic Valve Thrombosis, Thrombolytic Therapy, Streptokinase
by single disc valve 4 years ago. She presented at this admission with a new onset of congestive heart
failure. The prothrombin time was inadequate with international normalized ratio (INR) 1.43. Trans-
thoracic echocardiography revealed high pressure gradient across the mitral valve. Fluoroscopy demon-
strated restrictive opening of single disc motion. Intravenous thrombolysis was given for presumptive
diagnosis of prosthetic valve thrombosis. The patient gradually improved and did not have to undergo
surgical correction.
Key word : Prosthetic Valve Thrombosis, Thrombolytic Therapy, Streptokinase
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