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Original ArticleOpen Access
Pharmacokinetics of Ofloxacin in Drug-Resistant Tuberculosis
Chulavatnato S 
,
Chindavijak B ,
Chierakul N ,
Klomsawat D
,
Chindavijak B ,
Chierakul N ,
Klomsawat D BUSBA CHINDA VIJAK, PhD*,
DUANGRAT KLOMSAWAT, BS*
The pharmacokinetics of otloxacin were investigated in 11 drug-resistant pulmonary tuber-
culosis (TB) patients with a mean age (SO) of 38.09 (11.97) years. All patients received otloxacin 10
mg/kg once daily combined with other active anti-TB drugs. Following an 8-h overnight fast, serum
samples were drawn prior to and from 0.25 up to 24 hours after dosing. Serum otloxacin concentrations
were determined by high performance liquid chromatography (HPLC) assay.
Pharmacokinetics of otloxacin were well described by a linear, 2-compartment open model
with first-order absorption and first-order elimination. Meanเธ‘ SD of Cmax was 9.61 เธ‘ 2.17
~g/ml
occurred
at 1.68 เธ‘ 1.21 hours. Meansเธ‘ SD of AUC
0
_
24
and AUC
0
_
were 70.57 เธ‘ 26.40 and 82.45 เธ‘ 43.64
~g
x
h/ml, respectively. Ofloxacin distributed widely with a meanเธ‘ SD of VjF of 1.37 เธ‘ 0.24 L/kg. Meanเธ‘
SD of CL/F was 8.19 เธ‘ 2.53 L/h, whereas mean เธ‘ SD of
T
112~
and mean residence time were 8.03 เธ‘ 3.37
and 10.77 เธ‘ 4.55 hours, respectively. The free CmJMIC of
Mycobacterium tuberculosis
of7.7-15.4: 1
was estimated. These suggested that ofloxacin 10 mg/kg once daily combined with other active anti-
TB drugs provides sufficient Cm .. IMIC ratio and long
T
112~
which supported its use in drug-resistant TB.
Key word : Ofloxacin, Pharmacokinetics, Drug-Resistant Tuberculosis
DUANGRAT KLOMSAWAT, BS*
The pharmacokinetics of otloxacin were investigated in 11 drug-resistant pulmonary tuber-
culosis (TB) patients with a mean age (SO) of 38.09 (11.97) years. All patients received otloxacin 10
mg/kg once daily combined with other active anti-TB drugs. Following an 8-h overnight fast, serum
samples were drawn prior to and from 0.25 up to 24 hours after dosing. Serum otloxacin concentrations
were determined by high performance liquid chromatography (HPLC) assay.
Pharmacokinetics of otloxacin were well described by a linear, 2-compartment open model
with first-order absorption and first-order elimination. Meanเธ‘ SD of Cmax was 9.61 เธ‘ 2.17
~g/ml
occurred
at 1.68 เธ‘ 1.21 hours. Meansเธ‘ SD of AUC
0
_
24
and AUC
0
_
were 70.57 เธ‘ 26.40 and 82.45 เธ‘ 43.64
~g
x
h/ml, respectively. Ofloxacin distributed widely with a meanเธ‘ SD of VjF of 1.37 เธ‘ 0.24 L/kg. Meanเธ‘
SD of CL/F was 8.19 เธ‘ 2.53 L/h, whereas mean เธ‘ SD of
T
112~
and mean residence time were 8.03 เธ‘ 3.37
and 10.77 เธ‘ 4.55 hours, respectively. The free CmJMIC of
Mycobacterium tuberculosis
of7.7-15.4: 1
was estimated. These suggested that ofloxacin 10 mg/kg once daily combined with other active anti-
TB drugs provides sufficient Cm .. IMIC ratio and long
T
112~
which supported its use in drug-resistant TB.
Key word : Ofloxacin, Pharmacokinetics, Drug-Resistant Tuberculosis
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