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Original ArticleOpen Access
Pharmacokinetics of My co phenolic Acid in Kidney Transplant Recipients Treated with a Low Dose (1 gram/day) of Mycophenolate Mofetil
Julasareekul W 
,
EiamOng S ,
Bejraputra O ,
Seublinvong T
,
EiamOng S ,
Bejraputra O ,
Seublinvong T SOMCHAI EIAM-ONG, MD**,
T ADA SEUBLINVONG, MD***
Pharmacokinetic studies of mycophenolic acid (MPA) were performed in 16 stable Thai
kidney transplant recipients treated with 1 g/d of mycophenolate mofetil (MMF). The complete area
under the blood concentration-time curve (AUC) of MPA was determined using the linear trapezoidal
rule from 8 concentrations at, 0, 1, 2, 3, 4, 6, 8, and 12 h after MMF administration. The mean values
of AUC
0
*
12
were 37.54
เธ‘
0.80 f.lg*h/ml. MPA concentrations at 8 h after dosing, not the trough or
maximum levels, showed the best correlation with AUCo.
12
(r
= 0.72). The equation model of abbre-
viated AUC of MPA, derived by multiple linear regression analysis, that had the highest correlation
(r
2
)
and lowest absolute prediction error (APE) was: AUC = 0.6 C
1
+
1.9 C
3
+
8.68 C
8
+
4.65 (r
2
= 0.92,
APE= 2.05
เธ‘
0.32%). The best abbreviated AUC equations obtained by linear trapezoidal rule were :
AUC = 4.5 C
0
+
C
1
+
1.5 C
2
+
5 C
4
(r2 = 0.78, APE= 5.78
เธ‘
1.14%) and AUC = 5 Cl)
+
C
1
+
C
2
+
5 C
3
(r
2
= 0.76, APE= 6.21
เธ‘
1.46%)
Key word : Pharmacokinetic Studies, Mycophenolic Acid, Mycophenolate Mofetil
T ADA SEUBLINVONG, MD***
Pharmacokinetic studies of mycophenolic acid (MPA) were performed in 16 stable Thai
kidney transplant recipients treated with 1 g/d of mycophenolate mofetil (MMF). The complete area
under the blood concentration-time curve (AUC) of MPA was determined using the linear trapezoidal
rule from 8 concentrations at, 0, 1, 2, 3, 4, 6, 8, and 12 h after MMF administration. The mean values
of AUC
0
*
12
were 37.54
เธ‘
0.80 f.lg*h/ml. MPA concentrations at 8 h after dosing, not the trough or
maximum levels, showed the best correlation with AUCo.
12
(r
= 0.72). The equation model of abbre-
viated AUC of MPA, derived by multiple linear regression analysis, that had the highest correlation
(r
2
)
and lowest absolute prediction error (APE) was: AUC = 0.6 C
1
+
1.9 C
3
+
8.68 C
8
+
4.65 (r
2
= 0.92,
APE= 2.05
เธ‘
0.32%). The best abbreviated AUC equations obtained by linear trapezoidal rule were :
AUC = 4.5 C
0
+
C
1
+
1.5 C
2
+
5 C
4
(r2 = 0.78, APE= 5.78
เธ‘
1.14%) and AUC = 5 Cl)
+
C
1
+
C
2
+
5 C
3
(r
2
= 0.76, APE= 6.21
เธ‘
1.46%)
Key word : Pharmacokinetic Studies, Mycophenolic Acid, Mycophenolate Mofetil
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