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Original ArticleOpen Access
No Effect of Garlic Extract Supplement on Serum Lipid Levels in Hypercholesterolemic Subjects
Satitvipawee P 
,
Rawdaree P ,
Jndrabhakti S ,
Ratanasuwan T ,
Getngern P ,
Viwatwongkasem C
,
Rawdaree P ,
Jndrabhakti S ,
Ratanasuwan T ,
Getngern P ,
Viwatwongkasem C PETCH RA WDAREE, MD, MSc**,
TANAPORN RATANASUWAN, MD***,
CHUKIAT VIWATWONGKASEM, MSc*
Objective : The authors assessed the effects of an enteric-coated Thai garlic extract tablet
standardized for allicin-releasing potential on serum lipid levels in hypercholesterolemic subjects.
Subjects and Method : The authors performed a randomized, double-blind, placebo-con-
trolled trial in 136 hypercholesterolemic subjects (cholesterol
concentrations~
5.2 mmoi!L; mean ageเธ‘
SD: 47.0 เธ‘ 6.6 yr). All subjects were given dietary advice to lower fat intake within 4 weeks and were
advised to eat normally during the study period. The subjects were randomly assigned to receive an
enteric-coated Thai garlic extract tablet once daily (standardized to 1.12% allicin or 5.6 mg/tablet), or
placebo after the evening meal for 12 weeks. Seventy subjects (32.9% male; mean ageเธ‘ SD and BMI
of 47.0 เธ‘ 6.6 yr and 24.6 เธ‘ 3.3 kg/m
2
)
received the garlic extract treatment while 66 subjects (37.9%
male, mean ageเธ‘ SD and BMI of 47.0 เธ‘ 6.0 yr and 24.3 เธ‘ 3.4 kg/m
2
)
received placebo.
Results : There were no statistically significant changes in serum total cholesterol, trigly-
cerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol after
the 12-week treatment as analyzed on repeated measures by analysis of variance. In addition, no changes
in plasma glucose, liver and renal functions were found.
Conclusions : Treatment with an enteric garlic-coated Thai garlic extract and dietary advice
did not produce any significant changes in lipid levels in subjects with hypercholesterolemia.
Key word : Allicin, Garlic Extract Supplement, Serum Lipids, Hypercholesterolemic Subjects
TANAPORN RATANASUWAN, MD***,
CHUKIAT VIWATWONGKASEM, MSc*
Objective : The authors assessed the effects of an enteric-coated Thai garlic extract tablet
standardized for allicin-releasing potential on serum lipid levels in hypercholesterolemic subjects.
Subjects and Method : The authors performed a randomized, double-blind, placebo-con-
trolled trial in 136 hypercholesterolemic subjects (cholesterol
concentrations~
5.2 mmoi!L; mean ageเธ‘
SD: 47.0 เธ‘ 6.6 yr). All subjects were given dietary advice to lower fat intake within 4 weeks and were
advised to eat normally during the study period. The subjects were randomly assigned to receive an
enteric-coated Thai garlic extract tablet once daily (standardized to 1.12% allicin or 5.6 mg/tablet), or
placebo after the evening meal for 12 weeks. Seventy subjects (32.9% male; mean ageเธ‘ SD and BMI
of 47.0 เธ‘ 6.6 yr and 24.6 เธ‘ 3.3 kg/m
2
)
received the garlic extract treatment while 66 subjects (37.9%
male, mean ageเธ‘ SD and BMI of 47.0 เธ‘ 6.0 yr and 24.3 เธ‘ 3.4 kg/m
2
)
received placebo.
Results : There were no statistically significant changes in serum total cholesterol, trigly-
cerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol after
the 12-week treatment as analyzed on repeated measures by analysis of variance. In addition, no changes
in plasma glucose, liver and renal functions were found.
Conclusions : Treatment with an enteric garlic-coated Thai garlic extract and dietary advice
did not produce any significant changes in lipid levels in subjects with hypercholesterolemia.
Key word : Allicin, Garlic Extract Supplement, Serum Lipids, Hypercholesterolemic Subjects
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