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Original ArticleOpen Access
Comparison of Different Doses of Epidural Morphine for Pain Relief Following Cesarean Section
Chumpathong S 
,
Santawat U ,
Saunya P ,
Chimpalee R ,
Toomtong P
,
Santawat U ,
Saunya P ,
Chimpalee R ,
Toomtong P UBORAT SANTAWAT, M.D.*,
RUNGRUEDEE CHIMPALEE,M.D.*,
Although epidural opioid analgesia after cesarean section can provide excellent postopera-
tive pain relief, serious complications may occur after epidural morphine. Therefore, we performed
this study to compare the efficacy and side effects of three different doses of epidural morphine for
analgesia following cesarean section.
Ninety healthy pregnant women who underwent cesarean delivery were randomly assigned
to receive either 2.5, 3 or 4 mg of epidural morphine for postoperative analgesia. Pain intensity at rest
and on movement using a visual analogue scale (0-10) was regularly assessed for 48 hours, the time
to first analgesic requirement, the total analgesic dose, patient satisfaction and side effects were
recorded. Chi square and ANOV A tests were used for statistical analyses.
We were unable to demonstrate any difference in pain relief, patient satisfaction, and side
effects among the three groups. Epidural morphine provided sufficient pain relief for approximately
24 hours. About 27 per cent of the patients from each group were pain-free for up to 48 hours without
further analgesics. Mild pruritus and nausea occurred in all three groups and there was no significant
difference between them. No serious complications were observed. In conclusion low dose epidural
morphine is effective in providing adequate analgesia following cesarean delivery.
Key word : Epidural Morphine, Pain Therapy, Cesarean Section
CHUMPATHONG S, SANTAWAT U,
SAUNYA P, CHIMPALEE
RUNGRUEDEE CHIMPALEE,M.D.*,
Although epidural opioid analgesia after cesarean section can provide excellent postopera-
tive pain relief, serious complications may occur after epidural morphine. Therefore, we performed
this study to compare the efficacy and side effects of three different doses of epidural morphine for
analgesia following cesarean section.
Ninety healthy pregnant women who underwent cesarean delivery were randomly assigned
to receive either 2.5, 3 or 4 mg of epidural morphine for postoperative analgesia. Pain intensity at rest
and on movement using a visual analogue scale (0-10) was regularly assessed for 48 hours, the time
to first analgesic requirement, the total analgesic dose, patient satisfaction and side effects were
recorded. Chi square and ANOV A tests were used for statistical analyses.
We were unable to demonstrate any difference in pain relief, patient satisfaction, and side
effects among the three groups. Epidural morphine provided sufficient pain relief for approximately
24 hours. About 27 per cent of the patients from each group were pain-free for up to 48 hours without
further analgesics. Mild pruritus and nausea occurred in all three groups and there was no significant
difference between them. No serious complications were observed. In conclusion low dose epidural
morphine is effective in providing adequate analgesia following cesarean delivery.
Key word : Epidural Morphine, Pain Therapy, Cesarean Section
CHUMPATHONG S, SANTAWAT U,
SAUNYA P, CHIMPALEE
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