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Original ArticleOpen Access
Vigabatrin Therapy in Infantile Spasms
Kankirawatana P 
,
Raksadawan N ,
Balangkura K
,
Raksadawan N ,
Balangkura K PONGKIAT KANKIRAWATANA, M.D.*,
NATTEE RAKSADAWAN, M.D.*,
KAMPANAD BALANGKURA, M.D.*
Rationale : To determine the clinical outcome and side effects of vigabatrin (VGB) in the
treatment of infantile spasms (IS) and its long-term outcome.
Method : All children with IS treated with vigabatrin were studied. Clinical data regarding
age of onset, duration of IS before therapy started, recurrence of IS, types of seizures that relapse,
clinical outcome and side effects were monitored.
Results: 36 children (17 girls, 19 boys) with IS participated in the study. The mean age
of onset of IS was 115.55 เธ‘ 67.3 days old (range, 15 to 300 days). Six were cryptogenic IS and
30 were symptomatic IS. The etiologies of symptomatic IS in this study were tuberous sclerosis
NATTEE RAKSADAWAN, M.D.*,
KAMPANAD BALANGKURA, M.D.*
Rationale : To determine the clinical outcome and side effects of vigabatrin (VGB) in the
treatment of infantile spasms (IS) and its long-term outcome.
Method : All children with IS treated with vigabatrin were studied. Clinical data regarding
age of onset, duration of IS before therapy started, recurrence of IS, types of seizures that relapse,
clinical outcome and side effects were monitored.
Results: 36 children (17 girls, 19 boys) with IS participated in the study. The mean age
of onset of IS was 115.55 เธ‘ 67.3 days old (range, 15 to 300 days). Six were cryptogenic IS and
30 were symptomatic IS. The etiologies of symptomatic IS in this study were tuberous sclerosis
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