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Original ArticleOpen Access
Exercise-Induced Asthma Among Thai Asthmatic Children
Vichyanond P 
,
Anuraklekha P ,
Ruengruk S
,
Anuraklekha P ,
Ruengruk S PAKIT VICHYANOND, M.D.*,
PREMV ADEE ANURAKLEKHA, M.D.*,
SIRIRUT RUENGRUK, B.Sc.*
Background:
Approximately seventy per cent of asthmatic children from temperate climates,
with normal lung function, have exercise-induced asthma (EIA). There is certain evidence to suggest
that EIA may be less frequently encountered among children who live in tropical climates. Prevalence
of EIA in Asian asthmatic children has never been thoroughly studied.
Objective:
To study the prevalence of EIA among Thai asthmatic children.
Method:
A prospective study was performed to determine the prevalence of EIA in 44
Thai asthmatic children who were able to perform the spirometric maneuver. Subjects were randomly
selected asthmatic children from the Pediatric Allergy Clinic, Department of Pediatrics, Siriraj Hos-
pital. They were subjected to exercise testing on a steady state, motor-driven treadmill for 6 minutes
(mean speedเธ‘ SD
=
3.7
เธ‘
0.4 krnlh, mean level of inclinationเธ‘ SD
=
15.0
เธ‘
5.2 degrees). The testing
was conducted in a temperature-controlled (mean temperature เธ‘ SD
=
24.4
เธ‘
O.sเธ—q
and humidity-
controlled environment (mean relative humidity เธ‘ SD
=
41.7
เธ‘
2.1 %). Lung function tests were
performed before exercise, immediately after and at 3, 5, 10, 15, 20 and 30 minutes after exercise.
Results of the lung function test were calculated as per cent falls of forced expiratory volume in 1
sec (FEY,), peak expiratory flow rate (PEFR), and forced expiratory flow at 25 per cent-75 per cent
(FEF
50
)
from baselines. EIAs were diagnosed when drops of FEY
1
,
PEFR and FEF
50
were greater
than 20 per cent, 25 per cent and 25 per cent from baseline values, respectively.
Results:
Of the 44 patients studied (31 boys and 13 girls; mean age 11.9 years), 34 per
cent had mild asthma. Fifty-nine per cent had moderate asthma and 7 per cent had severe asthma.
Eleven patients (25%) had EIA diagnosed by significant falls of FEY
1
's (26 เธ‘ 12.6%), whereas, 13
patients (30%) and 20 patients (45%) had EIA defined by significant drops of PEFR's and FEF
50
's,
respectively. A total of 23 patients (52%) had EIA by one or more diagnostic criteria. Peak times
for EIA as diagnosed by FEV
1
,
PEFR and FEF
50
occurred at 3, 10, and 10 minutes respectively, after
exercise. Most EIA episodes observed were of mild degree.
SS80
PREMV ADEE ANURAKLEKHA, M.D.*,
SIRIRUT RUENGRUK, B.Sc.*
Background:
Approximately seventy per cent of asthmatic children from temperate climates,
with normal lung function, have exercise-induced asthma (EIA). There is certain evidence to suggest
that EIA may be less frequently encountered among children who live in tropical climates. Prevalence
of EIA in Asian asthmatic children has never been thoroughly studied.
Objective:
To study the prevalence of EIA among Thai asthmatic children.
Method:
A prospective study was performed to determine the prevalence of EIA in 44
Thai asthmatic children who were able to perform the spirometric maneuver. Subjects were randomly
selected asthmatic children from the Pediatric Allergy Clinic, Department of Pediatrics, Siriraj Hos-
pital. They were subjected to exercise testing on a steady state, motor-driven treadmill for 6 minutes
(mean speedเธ‘ SD
=
3.7
เธ‘
0.4 krnlh, mean level of inclinationเธ‘ SD
=
15.0
เธ‘
5.2 degrees). The testing
was conducted in a temperature-controlled (mean temperature เธ‘ SD
=
24.4
เธ‘
O.sเธ—q
and humidity-
controlled environment (mean relative humidity เธ‘ SD
=
41.7
เธ‘
2.1 %). Lung function tests were
performed before exercise, immediately after and at 3, 5, 10, 15, 20 and 30 minutes after exercise.
Results of the lung function test were calculated as per cent falls of forced expiratory volume in 1
sec (FEY,), peak expiratory flow rate (PEFR), and forced expiratory flow at 25 per cent-75 per cent
(FEF
50
)
from baselines. EIAs were diagnosed when drops of FEY
1
,
PEFR and FEF
50
were greater
than 20 per cent, 25 per cent and 25 per cent from baseline values, respectively.
Results:
Of the 44 patients studied (31 boys and 13 girls; mean age 11.9 years), 34 per
cent had mild asthma. Fifty-nine per cent had moderate asthma and 7 per cent had severe asthma.
Eleven patients (25%) had EIA diagnosed by significant falls of FEY
1
's (26 เธ‘ 12.6%), whereas, 13
patients (30%) and 20 patients (45%) had EIA defined by significant drops of PEFR's and FEF
50
's,
respectively. A total of 23 patients (52%) had EIA by one or more diagnostic criteria. Peak times
for EIA as diagnosed by FEV
1
,
PEFR and FEF
50
occurred at 3, 10, and 10 minutes respectively, after
exercise. Most EIA episodes observed were of mild degree.
SS80
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