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Original ArticleOpen Access
Thyrotropin Screening for congenital Hypothyroidism in Queen Sirikit National Institute of Child Health, Thailand (During year 1995-2000) Sunchai Chursigaew, M.D ..
Ratrisawasdi V 
,
Thaeramanophab S
,
Thaeramanophab S Objectives : To detect newborns with congenital hypothyroidism (CH) by TSH screening
and to treat the affected infants as early as possible. To find the incidence of CH in neonates born
at Rajavithi Hospital from 1995 to 2000. The effects of thyroid pathology, ages at the initiation of
treatment, associated conditions, and severity of CH on the intellectual outcome of the patients were
also analyzed.
Study designs : Thyrotropin (TSH) screening for CH in Queen Sirikit National Institute
of Child Health was done in neonates born at Rajavithi Hospital from 1995 to 2000. Infants with
elevated TSH level of greater than 25 mUlL were recalled for tests including serum T
4
,
TSH and
roentgenogram of bone age. Infants with CH were treated with Ievothyroxine 10-12 Ug/Kg/day :
growth and development, serum T
4
,
TSH were followed-up every 3 months for at least 2 years
to keep serum T
4
between 10-14 Ug/dL and serum TSH below 6 mUlL. Levothyroxine was dis-
continued for 4 weeks when the infants were over 2 years old. Serum T
4
,
TSH, thyroid scan, and
uptake were then performed on these infants. The patients must be euthyroid at the time of the
intelligence testing. The Stanford Binet or Vineland Social Maturity scale was used to evaluate the
patient's intelligence between the ages of 2 and
5
years.
Results: From 1995 to 2000, 62,681 neonates were screened for CH. The incidence of CH
was 1 : 4,178 live births. The sex ratio female : male 2 : 1. Fifteen infants with CH were started on
levothyroxine 10-12 Ug/Kg/day orally once a day. The age of initiation of treatment was between
2-8 weeks. There were 4 patients with lingual thyroid, 4 patients with thyroid hypoplasia, 2 patients
with thyroid aplasia and one patient with organification defect. The average intelligence score was
93.8. The factor that significantly affected the intellectual outcome of the patients was associated
with adverse conditions such as prematurity with complications, epilepsy and family disruption
(p
and to treat the affected infants as early as possible. To find the incidence of CH in neonates born
at Rajavithi Hospital from 1995 to 2000. The effects of thyroid pathology, ages at the initiation of
treatment, associated conditions, and severity of CH on the intellectual outcome of the patients were
also analyzed.
Study designs : Thyrotropin (TSH) screening for CH in Queen Sirikit National Institute
of Child Health was done in neonates born at Rajavithi Hospital from 1995 to 2000. Infants with
elevated TSH level of greater than 25 mUlL were recalled for tests including serum T
4
,
TSH and
roentgenogram of bone age. Infants with CH were treated with Ievothyroxine 10-12 Ug/Kg/day :
growth and development, serum T
4
,
TSH were followed-up every 3 months for at least 2 years
to keep serum T
4
between 10-14 Ug/dL and serum TSH below 6 mUlL. Levothyroxine was dis-
continued for 4 weeks when the infants were over 2 years old. Serum T
4
,
TSH, thyroid scan, and
uptake were then performed on these infants. The patients must be euthyroid at the time of the
intelligence testing. The Stanford Binet or Vineland Social Maturity scale was used to evaluate the
patient's intelligence between the ages of 2 and
5
years.
Results: From 1995 to 2000, 62,681 neonates were screened for CH. The incidence of CH
was 1 : 4,178 live births. The sex ratio female : male 2 : 1. Fifteen infants with CH were started on
levothyroxine 10-12 Ug/Kg/day orally once a day. The age of initiation of treatment was between
2-8 weeks. There were 4 patients with lingual thyroid, 4 patients with thyroid hypoplasia, 2 patients
with thyroid aplasia and one patient with organification defect. The average intelligence score was
93.8. The factor that significantly affected the intellectual outcome of the patients was associated
with adverse conditions such as prematurity with complications, epilepsy and family disruption
(p
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