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Original ArticleOpen Access
Comparative Study of the Effectiveness of Zuclopenthixol Acetate and Haloperidol in Acutely Disturbed Psychotic Patients
Taymeeyapradit U 
,
Kuasirikul S
,
Kuasirikul S UNCHULEE TAYMEEYAPRADIT, M.D.*,
SURACHAI KUASIRIKUL, M.D.**
Objectives : To study the effectiveness, frequency of administration and side effects of zuclo-
penthixol acetate (ZPT A) and haloperidol (HAL) in the treatment of acute psychotic disturbance with
aggression.
Method : Purposive sampling method was employed in a group of psychotic patients with
aggression admitted to Songkla Neuropsychiatric Hospital, they were randomly divided into 2 groups:
ZPT A group and HAL group. All of the patients were evaluated daily for 7 consecutive days using the
Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impression Scale (CGI). Statistical
analysis was performed by using the Student t-test and Linear regression.
Results : There were 70 patients with diagnosis of schizophrenia, mania and acute psy-
chosis. Thirty-eight patients were randomly assigned to the ZPTA group and were given 50-100
mg of the drug, while 32 patients received HAL 5-10 mg. The result showed a significant reduction
in BPRS or CGI scores in both groups. Patients treated with
ZPT
A required less frequent administra-
tion than did those on HAL (p
<
0.05). There was no statistically significant difference in the reduc-
tion in scores between the two groups. Nor was there a statistical difference in reduction of aggression
based on BPRS rating. Each group of patients showed a few side effects of mild degree.
Conclusion : Both ZPTA and HAL were effective in the treatment of acute psychosis with
aggression, but frequency of administration was lower in the
ZPT
A group
Key word : Effectiveness, Aggression, Acute Psychosis, Zuclopenthixol Acetate, Haloperidol
SURACHAI KUASIRIKUL, M.D.**
Objectives : To study the effectiveness, frequency of administration and side effects of zuclo-
penthixol acetate (ZPT A) and haloperidol (HAL) in the treatment of acute psychotic disturbance with
aggression.
Method : Purposive sampling method was employed in a group of psychotic patients with
aggression admitted to Songkla Neuropsychiatric Hospital, they were randomly divided into 2 groups:
ZPT A group and HAL group. All of the patients were evaluated daily for 7 consecutive days using the
Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impression Scale (CGI). Statistical
analysis was performed by using the Student t-test and Linear regression.
Results : There were 70 patients with diagnosis of schizophrenia, mania and acute psy-
chosis. Thirty-eight patients were randomly assigned to the ZPTA group and were given 50-100
mg of the drug, while 32 patients received HAL 5-10 mg. The result showed a significant reduction
in BPRS or CGI scores in both groups. Patients treated with
ZPT
A required less frequent administra-
tion than did those on HAL (p
<
0.05). There was no statistically significant difference in the reduc-
tion in scores between the two groups. Nor was there a statistical difference in reduction of aggression
based on BPRS rating. Each group of patients showed a few side effects of mild degree.
Conclusion : Both ZPTA and HAL were effective in the treatment of acute psychosis with
aggression, but frequency of administration was lower in the
ZPT
A group
Key word : Effectiveness, Aggression, Acute Psychosis, Zuclopenthixol Acetate, Haloperidol
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