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Original ArticleOpen Access
Increasing Trend of Illicit Drug Abuse in Thai Parturient at Siriraj Hospital
Inthawiwat S 
,
Rattanachaiyanont M ,
Leerasiri P ,
Manoch D ,
Titapant V
,
Rattanachaiyanont M ,
Leerasiri P ,
Manoch D ,
Titapant V MANEE RATTANACHAIYANONT, M.D.*,
DARAPA MANOCH,M.D.*,
Objective : To report the magnitude of the problem and to evaluate the outcome of maternal
illicit drug use in Thai parturients.
Design : Retrospective case-control study.
Setting : Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital,
Mahidol University.
Subject : The subjects were 44,640 parturients who had deliveries at Siriraj Hospital from
January 1998 to December 2001 and were divided into two groups. The study group consisted of
66 parturients with a history of illicit drug use and the control group consisted of 44,574 parturients
without a history of illicit drug use.
Intervention : Medical records of 66 parturients with a history of illicit drug use were
reviewed. Obstetric statistics of the department were retrieved from the computerized database in the
Division of Obstetric and Gynecologic Registry. The data were analyzed using descriptive statistics.
Main outcome measure : Characteristics of parturients, pregnancy outcome, type and inci-
dence of illicit drug.
Results : Within the study period, 66 cases of maternal illicit drug use were identifiable
during the intrapartum period; 65 cases used amphetamine or derivatives and 1 case used an opioid
derivative. The number had risen from 1 case in 1998 to 58 cases in 2001. Mean age of the patients
was 23.30
เธ‘
6.04 years. Compared to the control group which included 44,574 parturients, the patients
had a lower incidence of antenatal care (ANC rate = 21.21%
vs
94.35%; RR = 0.23, 95% CI = 0.14-
0.26), a higher incidence of HIV infection (10%
vs
2%; RR = 6.09, 95% Cl = 2.83-13.12), a higher
incidence of birth before arrival (BBA rate= 9.09%
vs
1.06%; RR = 8.59, 95% CI = 3.98-18.51),
and a lower cesarean section rate (10.60%
vs
26.36%; RR = 0.40, 95% CI = 0.20-0.81). There were
no serious intrapartum, immediate postpartum and neonatal complication. Fetal outcome included a
higher incidence of low birth weight infants (22.73%
vs
10.23%; RR = 2.22, 95% CI = 1.42-3.46) and
a smaller head circumference than the normal range of Thai fetal biometry (31.85
เธ‘
1.47 em).
1082
DARAPA MANOCH,M.D.*,
Objective : To report the magnitude of the problem and to evaluate the outcome of maternal
illicit drug use in Thai parturients.
Design : Retrospective case-control study.
Setting : Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital,
Mahidol University.
Subject : The subjects were 44,640 parturients who had deliveries at Siriraj Hospital from
January 1998 to December 2001 and were divided into two groups. The study group consisted of
66 parturients with a history of illicit drug use and the control group consisted of 44,574 parturients
without a history of illicit drug use.
Intervention : Medical records of 66 parturients with a history of illicit drug use were
reviewed. Obstetric statistics of the department were retrieved from the computerized database in the
Division of Obstetric and Gynecologic Registry. The data were analyzed using descriptive statistics.
Main outcome measure : Characteristics of parturients, pregnancy outcome, type and inci-
dence of illicit drug.
Results : Within the study period, 66 cases of maternal illicit drug use were identifiable
during the intrapartum period; 65 cases used amphetamine or derivatives and 1 case used an opioid
derivative. The number had risen from 1 case in 1998 to 58 cases in 2001. Mean age of the patients
was 23.30
เธ‘
6.04 years. Compared to the control group which included 44,574 parturients, the patients
had a lower incidence of antenatal care (ANC rate = 21.21%
vs
94.35%; RR = 0.23, 95% CI = 0.14-
0.26), a higher incidence of HIV infection (10%
vs
2%; RR = 6.09, 95% Cl = 2.83-13.12), a higher
incidence of birth before arrival (BBA rate= 9.09%
vs
1.06%; RR = 8.59, 95% CI = 3.98-18.51),
and a lower cesarean section rate (10.60%
vs
26.36%; RR = 0.40, 95% CI = 0.20-0.81). There were
no serious intrapartum, immediate postpartum and neonatal complication. Fetal outcome included a
higher incidence of low birth weight infants (22.73%
vs
10.23%; RR = 2.22, 95% CI = 1.42-3.46) and
a smaller head circumference than the normal range of Thai fetal biometry (31.85
เธ‘
1.47 em).
1082
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