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Original ArticleOpen Access
Serum Lipoprotein (a) Level and Restenosis After Percutaneous Coronary Intervention
Lolekha P 
,
Mahanonda N ,
Leowattana W ,
Pokum S ,
Kangkagate C
,
Mahanonda N ,
Leowattana W ,
Pokum S ,
Kangkagate C Restenosis After
NITHI MAHANONDA, M.D.**,
SASIKANT POKUM, B.Sc.
***,
Restenosis is regarded as the result of a combination of various pathological events. The
mechanisms are complex and not completely understood. In this study, the authors focused on
the lipoprotein (a) (Lp (a)). It is one of the novel risk factors in atherosclerotic vascular disease.
Numerous clinical studies suggest that individuals with elevated blood levels of Lp (a) have been
shown to be associated with atherosclerotic vascular disease. However, whether a high serum
concentration of Lp (a) affects restenosis after PCI remains controversial. In this study, the
relationship between serum Lp (a) levels and restenosis after PCI was examined to investigate
whether serum Lp (a) levels may be a predictor of restenosis after PCI. Of the 100 patients studied,
31 patients (31%) were classified as the restenosis group and 69 patients (69%) the non-restenosis
group. Both groups did not significantly differ in serum concentration of total cholesterol, trigly-
ceride, HDL-C, and LDL-C. The mean serum Lp (a) concentration in patients with restenosis was
41.50เธ‘34.99 mg/dL compared with a mean serum Lp (a) concentration of 29.87เธ‘25.47 mg/dL in
those without restenosis. There was no statistical significance of Lp (a) level between the restenosis
and non-restenosis groups (p=0.06). In healthy subjects, the normal reference range of serum Lp (a)
concentration is below 30 mg/dL. From this reference, if a cut off point of serum Lp (a) concen-
tration equal to 30 mg/dL or above to identify high Lp (a) level group was used. High serum Lp
(a) level was established in 15 patients with restenosis
versus
21 patients without restenosis. From
this cut off point of serum Lp (a) level, the authors did not find a correlation between serum Lp
(a) level and the restenosis group. (p=0.08).
Key word
: Serum Lipoprotein (a) Level, Restenosis, Percutaneous Coronary Intervention
NITHI MAHANONDA, M.D.**,
SASIKANT POKUM, B.Sc.
***,
Restenosis is regarded as the result of a combination of various pathological events. The
mechanisms are complex and not completely understood. In this study, the authors focused on
the lipoprotein (a) (Lp (a)). It is one of the novel risk factors in atherosclerotic vascular disease.
Numerous clinical studies suggest that individuals with elevated blood levels of Lp (a) have been
shown to be associated with atherosclerotic vascular disease. However, whether a high serum
concentration of Lp (a) affects restenosis after PCI remains controversial. In this study, the
relationship between serum Lp (a) levels and restenosis after PCI was examined to investigate
whether serum Lp (a) levels may be a predictor of restenosis after PCI. Of the 100 patients studied,
31 patients (31%) were classified as the restenosis group and 69 patients (69%) the non-restenosis
group. Both groups did not significantly differ in serum concentration of total cholesterol, trigly-
ceride, HDL-C, and LDL-C. The mean serum Lp (a) concentration in patients with restenosis was
41.50เธ‘34.99 mg/dL compared with a mean serum Lp (a) concentration of 29.87เธ‘25.47 mg/dL in
those without restenosis. There was no statistical significance of Lp (a) level between the restenosis
and non-restenosis groups (p=0.06). In healthy subjects, the normal reference range of serum Lp (a)
concentration is below 30 mg/dL. From this reference, if a cut off point of serum Lp (a) concen-
tration equal to 30 mg/dL or above to identify high Lp (a) level group was used. High serum Lp
(a) level was established in 15 patients with restenosis
versus
21 patients without restenosis. From
this cut off point of serum Lp (a) level, the authors did not find a correlation between serum Lp
(a) level and the restenosis group. (p=0.08).
Key word
: Serum Lipoprotein (a) Level, Restenosis, Percutaneous Coronary Intervention
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