J Med Assoc Thai 2001; 84 (9):1344

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Children's Plasma Cholinesterase Activity and Fatal Methomyl Poisoning
Ruangyuttikam W Mail, Phakdeewut T , Sainumtan W , Sribanditmongkol P

There is a case of a couple who intentionally killed their children with methomyl insec-
ticide. This was presented as our initial investigation of plasma cholinesterase (ChE) activity in
Thai children. A hundred and five healthy Thai children 5-6 years of age,
participate~
in the
project. Their plasma was drawn to measure ChE activity. Mean
เธ‘
standard deviation of the
children ChE was 7,417
เธ‘
1,620 UIL. The enzyme activity of the children was not significantly
different between gender and parents' occupations. However, the mean of female ChE activity
appeared to be lower than male ChE. Children whose parents were farmers appeared to have
lower ChE activity than those whose parents were employees, merchants, government officers,
unemployed parents, or private business owners. Two victims of child homicide were presented
with ChE activity approximately 6 and 9 per cent of the average, considering healthy children.
It
was concluded that children's plasma ChE activity lower than 10 per cent of normal, could be
a lethal indicator of anti-ChE insecticide poisoning.
Key word
: Children's Plasma Cholinesterase, Methomyl Poisoning

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