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Original ArticleOpen Access
An Effect of Hormone Replacement Therapy on Skin Thickness in Early Postmenopausal Women
Chotnopparatpattara P 
,
Panyakhamlerd K ,
Taechakraichana N ,
Tantivatana J ,
Chaikittisilpa S ,
Limpaphayom KK
,
Panyakhamlerd K ,
Taechakraichana N ,
Tantivatana J ,
Chaikittisilpa S ,
Limpaphayom KK Background:
It is well known that dermal thickness, the major component of skin thick-
ness, will decrease progressively after menopause. Bone and dermis share a similar organic
constituent (collagen type 1). The effect of hormone replacement therapy on bone has been
established, whereas, its effects on skin are less well-described. This study was performed to
determine the effect of combined estrogen-progestin replacement therapy in a sequential regimen
on skin thickness in women during the early postmenopausal period.
Method:
One hundred early postmenopausal women who met the eligibility criteria and
had already signed a consent form were non-randomly allocated in two groups. Group A; sixty
women who received cyclic hormone replacement therapy in each 28-day cycle for 6 cycles. Group
B; forty women who received 1,000 mg of calcium carbonate daily. Skin thickness was measured
by ultrasonography before and after treatment and the Student's
t-test
was used to compare the
results.
Results:
A statistically significant increase in skin thickness over baseline was noted after
combined estrogen-progestin replacement therapy had been administered for 24 weeks compared
to the control and baseline groups. The skin thickness was also significantly decreased after calcium
had been administered for 24 weeks when compared to baseline.
Conclusion:
Skin thickness was increased in early postmenopausal women subjected to
hormone replacement therapy with an alternating dose of estrogen and progestin.
Key word
: Hormone Replacement Therapy, Skin, Menopause, Estrogen, Progestin
It is well known that dermal thickness, the major component of skin thick-
ness, will decrease progressively after menopause. Bone and dermis share a similar organic
constituent (collagen type 1). The effect of hormone replacement therapy on bone has been
established, whereas, its effects on skin are less well-described. This study was performed to
determine the effect of combined estrogen-progestin replacement therapy in a sequential regimen
on skin thickness in women during the early postmenopausal period.
Method:
One hundred early postmenopausal women who met the eligibility criteria and
had already signed a consent form were non-randomly allocated in two groups. Group A; sixty
women who received cyclic hormone replacement therapy in each 28-day cycle for 6 cycles. Group
B; forty women who received 1,000 mg of calcium carbonate daily. Skin thickness was measured
by ultrasonography before and after treatment and the Student's
t-test
was used to compare the
results.
Results:
A statistically significant increase in skin thickness over baseline was noted after
combined estrogen-progestin replacement therapy had been administered for 24 weeks compared
to the control and baseline groups. The skin thickness was also significantly decreased after calcium
had been administered for 24 weeks when compared to baseline.
Conclusion:
Skin thickness was increased in early postmenopausal women subjected to
hormone replacement therapy with an alternating dose of estrogen and progestin.
Key word
: Hormone Replacement Therapy, Skin, Menopause, Estrogen, Progestin
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