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Original ArticleOpen Access
Clinical Use of Erythromycin in Children with Gastrointestinal Dysmotility
Aanpreung P 
,
Vajaradul C
,
Vajaradul C PRAPUN AANPREUNG, M.D.*,
CHIRASRI V AJARADUL, M.D.*
Intolerant feeding is a common symptom in gastrointestinal disorders which is commonly
found in systemic diseases. Prokinetic drugs play a role in management. A low dose of erythro-
mycin has an effect on improvement of antroduodenal motility and gastric emptying in children
and adults. The objective of this study was to evaluate the efficacy of intravenous erythromycin
in the treatment of GI dysmotility in children.
Retrospective studies were performed in the Department of Pediatrics, Siriraj Hospital,
Mahidol University between 1996 and 2000 in 22 patients with intolerance of feeding due to GI
dysmotility. Their ages ranged from 11 days to 12 years (42.1
เธ‘
48.1 months). The patients were
divided into 2 groups : 12 critically
ill
and 10 non-critically
ill
patients. Dosages of intravenous
erythromycin were 1-3 mg/kg/dose every 6 hours. The result of treatment was evaluated as : good
(tolerant feeding), fair (tolerant feeding but needing erythromycin for longer than I month) and
failed (intolerant feeding).
All non-critically ill patients had improved symptoms with 9
เธ‘
4.3 days duration of treat-
ment. In the other group, 8 patients had good results with 10.9
เธ‘
6 days of treatment. Two patients
needed the drug for longer than 1 month and the other 2 patients did not respond and died due
to severe infection. Low dose intravenous erythromycin had good efficacy in the treatment of
intolerant feeding related to GI dysmotility in children.
Key word
: Erythromycin, GI Dysmotility, Gastroparesis, Paralytic Ileus, Critically Ill, Tube
Feeding
CHIRASRI V AJARADUL, M.D.*
Intolerant feeding is a common symptom in gastrointestinal disorders which is commonly
found in systemic diseases. Prokinetic drugs play a role in management. A low dose of erythro-
mycin has an effect on improvement of antroduodenal motility and gastric emptying in children
and adults. The objective of this study was to evaluate the efficacy of intravenous erythromycin
in the treatment of GI dysmotility in children.
Retrospective studies were performed in the Department of Pediatrics, Siriraj Hospital,
Mahidol University between 1996 and 2000 in 22 patients with intolerance of feeding due to GI
dysmotility. Their ages ranged from 11 days to 12 years (42.1
เธ‘
48.1 months). The patients were
divided into 2 groups : 12 critically
ill
and 10 non-critically
ill
patients. Dosages of intravenous
erythromycin were 1-3 mg/kg/dose every 6 hours. The result of treatment was evaluated as : good
(tolerant feeding), fair (tolerant feeding but needing erythromycin for longer than I month) and
failed (intolerant feeding).
All non-critically ill patients had improved symptoms with 9
เธ‘
4.3 days duration of treat-
ment. In the other group, 8 patients had good results with 10.9
เธ‘
6 days of treatment. Two patients
needed the drug for longer than 1 month and the other 2 patients did not respond and died due
to severe infection. Low dose intravenous erythromycin had good efficacy in the treatment of
intolerant feeding related to GI dysmotility in children.
Key word
: Erythromycin, GI Dysmotility, Gastroparesis, Paralytic Ileus, Critically Ill, Tube
Feeding
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