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Original ArticleOpen Access
The Correlation of 8-Subunit Human Chorionic Gonadotropin Level in the Serum and First Morning Urine of Patients with Gestational Trophoblastic Disease
Benjapibal M 
,
Wataganara T ,
Senawong S ,
Boriboonhirunsam D ,
Suphanit I
,
Wataganara T ,
Senawong S ,
Boriboonhirunsam D ,
Suphanit I The purpose of this cross-sectional study was to determine the correlation of beta subunit
human chorionic gonadotropin
(~-hCG)
level in the serum and first morning urine samples of
patients with gestational trophoblastic disease (GTD). A total of 81 paired serum and first morning
urine samples from 24 patients diagnosed with GTD, who had their follow-up at the Division
of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj
Hospital, Mahidol University. The paired serum and first morning urine samples were measured
for
~-hCG
level, using enzyme-linked immunosorbent assay (ELISA). After logarithmic transfor-
mation, serum
~-hCG
level was strongly and significantly correlated to those of first morning urine
samples, with the correlation coefficient of 0.97 (p < 0.01). Among the disease-remission group
(serum
~-hCG
of less than 5 miU/ml), the correlation coefficient was 0.52 (p < 0.01), which was
still statistically significant. Stronger statistical significance was found in the disease-active group
(serum
~-hCG
of 5 miU/ml or higher), with the correlation coefficient of 0.95 (p
<
0.01). We
concluded that the level of serum
~-hCG
was strongly and significantly correlated with those of
first morning urine samples, especially in patients with active disease. Determination of
~-hCG
level
using first morning urine samples can be used as an effective mean in the follow-up of patients
with GTD.
Key word : Human Chorionic Gonadotropin, Gestational Trophoblastic Disease, First Morning
Urine
human chorionic gonadotropin
(~-hCG)
level in the serum and first morning urine samples of
patients with gestational trophoblastic disease (GTD). A total of 81 paired serum and first morning
urine samples from 24 patients diagnosed with GTD, who had their follow-up at the Division
of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj
Hospital, Mahidol University. The paired serum and first morning urine samples were measured
for
~-hCG
level, using enzyme-linked immunosorbent assay (ELISA). After logarithmic transfor-
mation, serum
~-hCG
level was strongly and significantly correlated to those of first morning urine
samples, with the correlation coefficient of 0.97 (p < 0.01). Among the disease-remission group
(serum
~-hCG
of less than 5 miU/ml), the correlation coefficient was 0.52 (p < 0.01), which was
still statistically significant. Stronger statistical significance was found in the disease-active group
(serum
~-hCG
of 5 miU/ml or higher), with the correlation coefficient of 0.95 (p
<
0.01). We
concluded that the level of serum
~-hCG
was strongly and significantly correlated with those of
first morning urine samples, especially in patients with active disease. Determination of
~-hCG
level
using first morning urine samples can be used as an effective mean in the follow-up of patients
with GTD.
Key word : Human Chorionic Gonadotropin, Gestational Trophoblastic Disease, First Morning
Urine
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