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Original ArticleOpen Access
Post-operative Nausea and Vomiting in Out-Patient Gynecologic Laparoscopy A Comparison of Thiopental -Nitrous Oxide, Propofol -Nitrous Oxide and Total Intravenous Anesthesia Using Propofol
Chanvej L 
,
Kijsirikul S ,
Thongsuksai P ,
Naheem L
,
Kijsirikul S ,
Thongsuksai P ,
Naheem L SIRIKUL KIJSIRIKUL, M.D.**'
LAEAD NAHEEM, RN*
An intravenous anesthetic drug, propofol was considered to pose antiemetic action. A
randomized controlled trial was conducted to evaluate whether propofol could effectively reduce
post-operative nausea and vomiting (PONV) compared to thiopental -nitrous oxide (Np). One-
hundred and eight patients undergoing outpatient gynecologic laparoscopy were assigned to
receive 3 techniques of anesthesia; thiopental-Np (TIN), propofol-Np (PIN) and total intra-
venous anesthesia (TIV A) using propofol (PIP). The results showed that in the early period (0-5
hours), post-operative nausea in
TIN, PIN
and
PIP
groups was 72 per cent, 44 per cent and 31 per
cent, respectively (P
=
0.002), and post-operative vomiting was 58 per cent, 36 per cent and 11 per
cent respectively (P
=
0.00014). Patients in the
PIN
and
PIP
groups experienced nausea less fre-
quently than the
TIN
group [relative risk (RR)
=
0.62, (95% CI 0.41-0.93) and RR
=
0.42 (0.25-
0.72) respectively]. Patients in the
PIN
and
PIP
groups experienced vomiting less frequently than
the
TIN
group [RR
=
0.62 (0.37-1.04) and RR
=
0.19 (0.07-0.5) respectively]. Two patients in the
TIN
group were admitted because of severe nausea and vomiting. In conclusion, TIV A using pro-
pofol and propofol-Np anesthesia can significantly reduce the incidence of PONV in the early
period. Concerning the economic crisis of the country as well as the quality of care, propofol-
Np
would be the most appropriate anesthetic of choice.
Key word
: Propofol, Thiopental, Nitrous Oxide, Outpatient Gynecologic Laparoscopy, Post-
operative Nausea and Vomiting
LAEAD NAHEEM, RN*
An intravenous anesthetic drug, propofol was considered to pose antiemetic action. A
randomized controlled trial was conducted to evaluate whether propofol could effectively reduce
post-operative nausea and vomiting (PONV) compared to thiopental -nitrous oxide (Np). One-
hundred and eight patients undergoing outpatient gynecologic laparoscopy were assigned to
receive 3 techniques of anesthesia; thiopental-Np (TIN), propofol-Np (PIN) and total intra-
venous anesthesia (TIV A) using propofol (PIP). The results showed that in the early period (0-5
hours), post-operative nausea in
TIN, PIN
and
PIP
groups was 72 per cent, 44 per cent and 31 per
cent, respectively (P
=
0.002), and post-operative vomiting was 58 per cent, 36 per cent and 11 per
cent respectively (P
=
0.00014). Patients in the
PIN
and
PIP
groups experienced nausea less fre-
quently than the
TIN
group [relative risk (RR)
=
0.62, (95% CI 0.41-0.93) and RR
=
0.42 (0.25-
0.72) respectively]. Patients in the
PIN
and
PIP
groups experienced vomiting less frequently than
the
TIN
group [RR
=
0.62 (0.37-1.04) and RR
=
0.19 (0.07-0.5) respectively]. Two patients in the
TIN
group were admitted because of severe nausea and vomiting. In conclusion, TIV A using pro-
pofol and propofol-Np anesthesia can significantly reduce the incidence of PONV in the early
period. Concerning the economic crisis of the country as well as the quality of care, propofol-
Np
would be the most appropriate anesthetic of choice.
Key word
: Propofol, Thiopental, Nitrous Oxide, Outpatient Gynecologic Laparoscopy, Post-
operative Nausea and Vomiting
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