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Original ArticleOpen Access
Adenocarcinoma of the Pancreas : The Clinical Experience of 45 Histopathologically Proven Patients, a 6 Year Study
Kulavanijaya P 
,
Treeprasertsuk S ,
ThongNgam D ,
Kladcharoen N ,
Mahachai V ,
Suwanagool P
,
Treeprasertsuk S ,
ThongNgam D ,
Kladcharoen N ,
Mahachai V ,
Suwanagool P A retrospective study of 45 cases of adenocarcinoma of the pancreas at Chulalongkorn
University Hospital from 1993 to 1998 was reviewed by clinical and histopathological criteria.
Male and female ratio was 25:20. The mean age of the patients was 59.5
เธ‘
10.0 years. The com-
mon presenting symptoms and signs were epigastric discomfort (80.0%), weight loss (60.0%) and
jaundice (51.1%). Twenty four patients (53.3%) were screened for a tumor marker (CA 19-9) and
87.5 per cent of these had high level of CA 19-9 (> 37 IU/ml). Thirty five patients (77.8%) had
tumors located in the head of the pancreas. Most of the cases were investigated by using radio-
logical imaging (ultrasonography or computerized tomography of the abdomen). Thirty five histo-
pathological data (77 .8%) were made by the operation, and the rest (22.2%) were performed by a
fine needle aspiration from the pancreatic mass or liver metastasis. Whipple operation and the
bypass procedure were the most common surgical procedures in our studies. Twenty five patients
(55.6%) had post treatment complications from all modalities consisting of gastrointestinal bleed-
ing, respiratory failure and infection. However, the mortality rate within 30 days postoperatively
was 8.11 per cent which was due to blood loss during the operation and infections. The post treat-
ment mortality rate from all modalities was 33.3 per cent. The average duration from the diagnosis
until death was 82.3 days.
Key word : Adenocarcinoma, Pancreas, Clinical, Histopathological
University Hospital from 1993 to 1998 was reviewed by clinical and histopathological criteria.
Male and female ratio was 25:20. The mean age of the patients was 59.5
เธ‘
10.0 years. The com-
mon presenting symptoms and signs were epigastric discomfort (80.0%), weight loss (60.0%) and
jaundice (51.1%). Twenty four patients (53.3%) were screened for a tumor marker (CA 19-9) and
87.5 per cent of these had high level of CA 19-9 (> 37 IU/ml). Thirty five patients (77.8%) had
tumors located in the head of the pancreas. Most of the cases were investigated by using radio-
logical imaging (ultrasonography or computerized tomography of the abdomen). Thirty five histo-
pathological data (77 .8%) were made by the operation, and the rest (22.2%) were performed by a
fine needle aspiration from the pancreatic mass or liver metastasis. Whipple operation and the
bypass procedure were the most common surgical procedures in our studies. Twenty five patients
(55.6%) had post treatment complications from all modalities consisting of gastrointestinal bleed-
ing, respiratory failure and infection. However, the mortality rate within 30 days postoperatively
was 8.11 per cent which was due to blood loss during the operation and infections. The post treat-
ment mortality rate from all modalities was 33.3 per cent. The average duration from the diagnosis
until death was 82.3 days.
Key word : Adenocarcinoma, Pancreas, Clinical, Histopathological
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