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Original ArticleOpen Access
Reticulocyte Analysis in Iron Deficiency Anemia and Hemolytic Anemia
Butthep P 
,
Wisedpanichkij R ,
Jindadamrongwech S ,
Kaewkethong P ,
Pattamakom S ,
SilaAsna M ,
Bunyaratvej A
,
Wisedpanichkij R ,
Jindadamrongwech S ,
Kaewkethong P ,
Pattamakom S ,
SilaAsna M ,
Bunyaratvej A RAEWADEE WISEDPANICHKU, M.Sc.*,
PREYARAT KAEWKETHONG, B.Sc.*,
MONNIPHA SILA-ASNA, M.Sc. *,
Reticulocyte analysis was studied in 28 anemic patients, 15 with iron deficiency anemia
(IDA), and 13 with hemolytic anemia including 9 glucose 6 phosphate dehydrogenase deficiency
(G6PD def.), and 4 with G6PD def. combined with HbE trait or
a
thalassemia trait
(a
thai trait).
The reticulocyte analysis among these patients showed the increased number of reticulocyte
percentage with low degree of maturation in both IDA and G6PD def. patients. The significantly
decreased reticulocyte hemoglobin content (CHr) was found in IDA (CHr= 21.74
เธ‘
4.61 pg in
IDA
vs
28.41
เธ‘
1.34 pg in normal; p-value =
<
0.0001), whereas, increased CHr was found in
G6PD def. patients. In addition, the G6PD def. patients also showed a significant increase in
mean corpuscular reticulocyte volume (MCVr) when compared to normal (MCVr = 132.0
เธ‘
8.39 fl. in G6PD def.
vs
110.39
เธ‘
5.09 in normal; p -value =
<
0.0001). However, a significant
decrease in MCVr was found in IDA patients (MCVr = 95.89
เธ‘
8.57 fl.; p-value =
<
0.0001
vs
normal). From this study, we can suggest that the reticulocyte hemoglobin content (CHr) and
mean corpuscular reticulocyte volume (MCVr) are the important defects in patients with iron
deficiency anemia.
Key word : Reticulocyte Analysis, Iron Deficiency Anemia, G6PD Deficiency
PREYARAT KAEWKETHONG, B.Sc.*,
MONNIPHA SILA-ASNA, M.Sc. *,
Reticulocyte analysis was studied in 28 anemic patients, 15 with iron deficiency anemia
(IDA), and 13 with hemolytic anemia including 9 glucose 6 phosphate dehydrogenase deficiency
(G6PD def.), and 4 with G6PD def. combined with HbE trait or
a
thalassemia trait
(a
thai trait).
The reticulocyte analysis among these patients showed the increased number of reticulocyte
percentage with low degree of maturation in both IDA and G6PD def. patients. The significantly
decreased reticulocyte hemoglobin content (CHr) was found in IDA (CHr= 21.74
เธ‘
4.61 pg in
IDA
vs
28.41
เธ‘
1.34 pg in normal; p-value =
<
0.0001), whereas, increased CHr was found in
G6PD def. patients. In addition, the G6PD def. patients also showed a significant increase in
mean corpuscular reticulocyte volume (MCVr) when compared to normal (MCVr = 132.0
เธ‘
8.39 fl. in G6PD def.
vs
110.39
เธ‘
5.09 in normal; p -value =
<
0.0001). However, a significant
decrease in MCVr was found in IDA patients (MCVr = 95.89
เธ‘
8.57 fl.; p-value =
<
0.0001
vs
normal). From this study, we can suggest that the reticulocyte hemoglobin content (CHr) and
mean corpuscular reticulocyte volume (MCVr) are the important defects in patients with iron
deficiency anemia.
Key word : Reticulocyte Analysis, Iron Deficiency Anemia, G6PD Deficiency
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