Views: 1,252 | Downloads:
38
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Different Reticulocyte Volume in Diabetes Mellitus Patients with and without Hypercholesterolemia and/or Hypertriglyceridemia
Bunyaratvej P 
,
Komindr S ,
Wisedpanichkij R
,
Komindr S ,
Wisedpanichkij R Red cells and reticulocytes from patients with diabetes mellitus (DM) were analysed
using laser and computer technology of H*3 hematology analyzer. Four groups of diabetes
mellitus patients: diabetes with normolipemia (DM) (n=l2) and DM patients with excess tri-
glyceride (DM-T) (n=7) or cholesterol (DM-C) (n=21) or both (DM-TC) (n=21) were studied.
Mean corpuscular volume of mature red cells (Meanเธ‘SD
=
93.6เธ‘5.5
fl)
and reticulocyte (119 .Iเธ‘
12.3
fl)
of patients with DM-T was not significantly increased from normal (red cell, 90.0เธ‘
3.5
fl;
reticulocyte, 115.2เธ‘7.3
fl).
Plasma triglyceride levels had no significant correlation with
red cell MCV, reticulocyte MCV and %Hb Ale. This suggests that high triglyceride levels in
DM are not dose-dependent in producing increased MCV of red cells and reticulocytes.
Comparing between DM-T and DM-C, red cells and reticulocytes from DM-C patients had
significantly decreased MCV (red cell, 85.5เธ‘6.1 tL; reticulocyte, 103.8เธ‘7.4
fL).
Plasma cho-
lesterol levels were inversely correlated with MCV of red cells (r=-0.377, p=0.003) and also
MCV of reticulocytes (r=-0.418, p=O.OOl). In addition, cholesterol levels showed considerable
correlation with Hb Ale (r=0.572, p=0.004). The red cell volume change in DM-C patients may
be partly due to the shift in balance of cholesterol exchange between red cell membranes and
serum lipoproteins.
Key word : Diabetes Mellitus, Hypercholesterolemia, Hypertriglyceridemia, Reticulocyte
using laser and computer technology of H*3 hematology analyzer. Four groups of diabetes
mellitus patients: diabetes with normolipemia (DM) (n=l2) and DM patients with excess tri-
glyceride (DM-T) (n=7) or cholesterol (DM-C) (n=21) or both (DM-TC) (n=21) were studied.
Mean corpuscular volume of mature red cells (Meanเธ‘SD
=
93.6เธ‘5.5
fl)
and reticulocyte (119 .Iเธ‘
12.3
fl)
of patients with DM-T was not significantly increased from normal (red cell, 90.0เธ‘
3.5
fl;
reticulocyte, 115.2เธ‘7.3
fl).
Plasma triglyceride levels had no significant correlation with
red cell MCV, reticulocyte MCV and %Hb Ale. This suggests that high triglyceride levels in
DM are not dose-dependent in producing increased MCV of red cells and reticulocytes.
Comparing between DM-T and DM-C, red cells and reticulocytes from DM-C patients had
significantly decreased MCV (red cell, 85.5เธ‘6.1 tL; reticulocyte, 103.8เธ‘7.4
fL).
Plasma cho-
lesterol levels were inversely correlated with MCV of red cells (r=-0.377, p=0.003) and also
MCV of reticulocytes (r=-0.418, p=O.OOl). In addition, cholesterol levels showed considerable
correlation with Hb Ale (r=0.572, p=0.004). The red cell volume change in DM-C patients may
be partly due to the shift in balance of cholesterol exchange between red cell membranes and
serum lipoproteins.
Key word : Diabetes Mellitus, Hypercholesterolemia, Hypertriglyceridemia, Reticulocyte
Download:
PDF