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Original ArticleOpen Access
Efficacy of UFT Plus Oral Leucovorin in Advanced Colorectal Cancer A Multicenter Study
Thongprasert S 
,
Maoleekoonpairoj S ,
Laohavinij S ,
Thavichaigam P
,
Maoleekoonpairoj S ,
Laohavinij S ,
Thavichaigam P Purpose
: To evaluate the efficacy and toxicity of
UFT
plus oral leucovorin in advanced
colorectal cancer.
Material and Method
: Twenty cases of advanced colorectal cancer were entered into
the study. All patients must have histologic proof and have measurable disease. Prior to the treat-
ment all patients should have normal baseline hematology and normal liver and renal function.
ECOG Performance status :::; 2 and age 18-75 years. Chemotherapeutic drugs consisted of
UFT
350 mg/m"/day divided into 3 doses (8 hours apart) plus oral leucovorin 15 mg every 8 hours.
Duration of treatment was 21 days per each cycle. Treatment was recycled every 28 days.
Results
: Four cases (22.2%) had partial responses and six cases (33.3%) had stable
disease. Duration of response was 4+-7+ months. Toxicity was darkened skin, mild diarrhea and
mild alopecia.
Conclusion
: UFT plus oral leucovorin was one of the active regimens in the treatment
of advanced colorectal cancer.
Key word
: Advanced Colorectal Cancer,
UFT,
Oral Leucovorin
: To evaluate the efficacy and toxicity of
UFT
plus oral leucovorin in advanced
colorectal cancer.
Material and Method
: Twenty cases of advanced colorectal cancer were entered into
the study. All patients must have histologic proof and have measurable disease. Prior to the treat-
ment all patients should have normal baseline hematology and normal liver and renal function.
ECOG Performance status :::; 2 and age 18-75 years. Chemotherapeutic drugs consisted of
UFT
350 mg/m"/day divided into 3 doses (8 hours apart) plus oral leucovorin 15 mg every 8 hours.
Duration of treatment was 21 days per each cycle. Treatment was recycled every 28 days.
Results
: Four cases (22.2%) had partial responses and six cases (33.3%) had stable
disease. Duration of response was 4+-7+ months. Toxicity was darkened skin, mild diarrhea and
mild alopecia.
Conclusion
: UFT plus oral leucovorin was one of the active regimens in the treatment
of advanced colorectal cancer.
Key word
: Advanced Colorectal Cancer,
UFT,
Oral Leucovorin
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