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Original ArticleOpen Access
Phase I Trial of Tropisetron and Dexamethasone in the Prevention of Cisplatin-Induced Emesis
Voravud N 
,
Suwanrusmee H
,
Suwanrusmee H Thirty-one patients treated with 58 cycles of cisplatin-based chemotherapy at a dose
>
80 mg/m
2
were enrolled into the study using tropisetron and dexamethasone in the prevention
of cisplatin-induced emesis. There was 87.9 per cent complete control, I 0.3 per cent major
control, and
I.
7 per cent failure for nausea episode on the first day of cycle. For the vomiting
control, there was 96.6 per cent complete control, 3.4 per cent major control, and no failure.
After the second day, the percentage of complete control increased gradually for both nausea and
vomiting. The complete control for acute nausea and vomiting was 85.7 per cent and 92.9
per cent, respectively. The efficacy for delayed emesis was lower. There was 76.4 per cent
complete control for delayed nausea and 85.7 per cent for delayed vomiting. The treatment
was well tolerated without any serious adverse events related to tropisetron. Only hiccups was
reported in 4 patients and recovered spontaneously at the end of the cycle. Combination of tro-
pisetron and dexamethasone is an effective and safe antiemetic regimen in the prevention of
cisplatin-induced emesis.
Key word : Tropisetron, Dexamethasone, Cisplatin-Induced Emesis
>
80 mg/m
2
were enrolled into the study using tropisetron and dexamethasone in the prevention
of cisplatin-induced emesis. There was 87.9 per cent complete control, I 0.3 per cent major
control, and
I.
7 per cent failure for nausea episode on the first day of cycle. For the vomiting
control, there was 96.6 per cent complete control, 3.4 per cent major control, and no failure.
After the second day, the percentage of complete control increased gradually for both nausea and
vomiting. The complete control for acute nausea and vomiting was 85.7 per cent and 92.9
per cent, respectively. The efficacy for delayed emesis was lower. There was 76.4 per cent
complete control for delayed nausea and 85.7 per cent for delayed vomiting. The treatment
was well tolerated without any serious adverse events related to tropisetron. Only hiccups was
reported in 4 patients and recovered spontaneously at the end of the cycle. Combination of tro-
pisetron and dexamethasone is an effective and safe antiemetic regimen in the prevention of
cisplatin-induced emesis.
Key word : Tropisetron, Dexamethasone, Cisplatin-Induced Emesis
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