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Original ArticleOpen Access
Comparison of Ofloxacin Otic Solution with Oral Amoxycillin Plus Chloramphenicol Ear Drop in Treatment of Chronic Suppurative Otitis Media with Acute Exacerbation
Supiyaphun P 
,
Kerekhanjanarong V ,
Koranasophonepun J ,
Sastarasadhit V
,
Kerekhanjanarong V ,
Koranasophonepun J ,
Sastarasadhit V The efficacy and safety of 0.3 per cent Ofloxacin otic solution (OFLX) 6 drops twice
daily was compared with those of oral Amoxycillin 500 mg three times daily plus 1 per cent
Chloramphenicol ear drop at 3 drops three times daily (AMOX+CRP) in a two-week treatment
of chronic suppurative otitis media (CSOM) with acute exacerbation. 80 adult patients were
enrolled in a prospective, randomized, investigator-blind study at the outpatient ENT service of
Chulalongkorn University Hospital.
The most common pathogens isolated at the pretreatment visit were Staphylococcus
aureus (30.3%) and Pseudomonas aeruginosa (24.7%). The susceptibility of all the pathogenic
isolates to ofloxacin, amoxycillin and chloramphenicol were 96.4, 57.1 and 51.8 per cent respec-
tively.
The overall response expressed as an improvement or cure of otalgia, otorrhea and
middle ear mucosal inflammation was recorded. It revealed that the improvement rate of the
OFLX-treated patients was better than that of AMOX+CRP-treated, but was not statistically
significant. However, the cure rate was significantly better in OFLX-treated than in AMOX+
CRP-treated groups in terms of painless (p=0.05) and dry (p
daily was compared with those of oral Amoxycillin 500 mg three times daily plus 1 per cent
Chloramphenicol ear drop at 3 drops three times daily (AMOX+CRP) in a two-week treatment
of chronic suppurative otitis media (CSOM) with acute exacerbation. 80 adult patients were
enrolled in a prospective, randomized, investigator-blind study at the outpatient ENT service of
Chulalongkorn University Hospital.
The most common pathogens isolated at the pretreatment visit were Staphylococcus
aureus (30.3%) and Pseudomonas aeruginosa (24.7%). The susceptibility of all the pathogenic
isolates to ofloxacin, amoxycillin and chloramphenicol were 96.4, 57.1 and 51.8 per cent respec-
tively.
The overall response expressed as an improvement or cure of otalgia, otorrhea and
middle ear mucosal inflammation was recorded. It revealed that the improvement rate of the
OFLX-treated patients was better than that of AMOX+CRP-treated, but was not statistically
significant. However, the cure rate was significantly better in OFLX-treated than in AMOX+
CRP-treated groups in terms of painless (p=0.05) and dry (p
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