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Original ArticleOpen Access
Diffuse Panbronchiolitis, the First Case Reports in Thailand
Chantarotom S 
,
Palwatwichai A ,
Vattanathum A ,
Tantamacharik D
,
Palwatwichai A ,
Vattanathum A ,
Tantamacharik D Diffuse panbronchiolitis (DPB) is an important cause of progressive obstructive lung or
chronic suppurative lung disease in the Far East (Japan, China and Korea). It is a distinctive sinobronchial
syndrome with typical radiological and histologic features. We have identified three
patients who have typical clinical manifestation and pathological confirmation. DPB should be
suspected in patients who have clinical manifestations of chronic cough, productive sputum and
shortness of breath. The chest radiograph often shows diffuse nodular shadows on a background of
hyperinflated lungs. High resolution computed tomographic (HRCT) can guide the diagnosis and
differentiate from other diseases. Finally, the most important issue of DPB is the treatment. Chronic
treatment with low-dose erythromycin can improve the survival of patients.
Key word : Diffuse Panbronchiolitis, Bronchiectasis
chronic suppurative lung disease in the Far East (Japan, China and Korea). It is a distinctive sinobronchial
syndrome with typical radiological and histologic features. We have identified three
patients who have typical clinical manifestation and pathological confirmation. DPB should be
suspected in patients who have clinical manifestations of chronic cough, productive sputum and
shortness of breath. The chest radiograph often shows diffuse nodular shadows on a background of
hyperinflated lungs. High resolution computed tomographic (HRCT) can guide the diagnosis and
differentiate from other diseases. Finally, the most important issue of DPB is the treatment. Chronic
treatment with low-dose erythromycin can improve the survival of patients.
Key word : Diffuse Panbronchiolitis, Bronchiectasis
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