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Original ArticleOpen Access
Tumor Angiogenesis
Voravud N 
,
Charuruk N
,
Charuruk N Tumor angiogenesis is the growth of new blood vessels which is required for tumor
growth and progression. Vascularization of the tumor occurs through a series of sequential steps
before or during the multistep progression to neoplasia. Several events occur during the formation
of new vessels including production of protease enzymes, unregulation of positive regulators of
angiogenesis, and down regulation of negative regulators. In addition, tumor associated macrophage
also influence angiogenesis by secreting enzymes, enzymes inhibitors and cytokines. Recent
knowledge in tumor angiogenesis may have clinical implications in diagnosis and treatment.
Quantification of microvessel density in tumor specimen correlates either metastasis or recurrence
in many malignancies such as breast cancer and lung cancer. Therefore, assessment of tumor
angiogenesis may serve as prognostic factors. Therapeutic applications include the development
of new agents with antiangiogenic properties, vascular targeting drugs, antibody-based therapy,
and gene therapy. Combination of antiangiogenic therapy with cytotoxic drugs may enhance
antitumor activity. Moreover, the role of antiangiogenic therapy in adjuvant setting may provide
and alternative approach to better cancer treatment in the near future.
Key word : Tumor Angiogenesis, Mechanism, Factors
growth and progression. Vascularization of the tumor occurs through a series of sequential steps
before or during the multistep progression to neoplasia. Several events occur during the formation
of new vessels including production of protease enzymes, unregulation of positive regulators of
angiogenesis, and down regulation of negative regulators. In addition, tumor associated macrophage
also influence angiogenesis by secreting enzymes, enzymes inhibitors and cytokines. Recent
knowledge in tumor angiogenesis may have clinical implications in diagnosis and treatment.
Quantification of microvessel density in tumor specimen correlates either metastasis or recurrence
in many malignancies such as breast cancer and lung cancer. Therefore, assessment of tumor
angiogenesis may serve as prognostic factors. Therapeutic applications include the development
of new agents with antiangiogenic properties, vascular targeting drugs, antibody-based therapy,
and gene therapy. Combination of antiangiogenic therapy with cytotoxic drugs may enhance
antitumor activity. Moreover, the role of antiangiogenic therapy in adjuvant setting may provide
and alternative approach to better cancer treatment in the near future.
Key word : Tumor Angiogenesis, Mechanism, Factors
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