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Original ArticleOpen Access
In Vitro Activity and Clinical Evaluation of Cefixime in Urinary Tract Infection
Asvanich K 
,
Fugplwlngam V ,
Srimuang S ,
Tanphaichitra D
,
Fugplwlngam V ,
Srimuang S ,
Tanphaichitra D Thirty-five women with uncomplicated acute lower urinary tract infections proven by
significant pre-treatment bacteriuria (≥ I05CFU/ml) were treated with an oral dose of 100 mg
cefixime twice a day for seven days.
Thirty five patients included in this study were checked for response to treatment on the
last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial
eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and
Proteus mirabilis, were inhibited at MIC90= 0.5 and ≤ 0.03 µg/ml, and MBC = 1 and 0.06
µg/ml respectively. No adverse events were found in this study.
significant pre-treatment bacteriuria (≥ I05CFU/ml) were treated with an oral dose of 100 mg
cefixime twice a day for seven days.
Thirty five patients included in this study were checked for response to treatment on the
last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial
eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and
Proteus mirabilis, were inhibited at MIC90= 0.5 and ≤ 0.03 µg/ml, and MBC = 1 and 0.06
µg/ml respectively. No adverse events were found in this study.
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